Antianaphylactic and Antipruritic Effects of the Flowers of Impatiens textori MIQ.(Pharmacognosy)
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概要
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The anti-anaphylactic and anti-pruritic activities of a 35% EtOH extract (IT) of the flowers of Impatiens textori MIQ. were investigated by in vivo assay. IT and apigenin (1), apigenin 7-glucoside (2) and luteolin (3), principal compounds from IT, inhibited compound 48/80 (COM)-induced by blood pressure (BP) decrease, which was an immunoglobulin (Ig)E-independent anaphylaxis-like response. Compounds 1-3 all inhibited BP decrease induced by IgE-dependent anaphylaxis. Furthermore, IT also inhibited the blood flow (BF) decrease induced by antigen-induced anaphylaxis in actively sensitized mice. IT showed a significant inhibitory effect on scratching behavior induced by COM without a central depressant. IT also significantly inhibited platelet activating factor (PAF)- and serotonin (5-HT)-induced scratching behavior and mitigated protease (PA)-induced scratching behavior. These findings showed that the flowers of I. textori can be utilized as an anti-anaphylactic and anti-pruritic agent in addition to the traditional applications of this plant.
- 公益社団法人日本薬学会の論文
- 2005-09-01
著者
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IINUMA Munekazu
Gifu Pharmaceutical University
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奥 尚枝
武庫川女大薬
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石黒 京子
武庫川女大薬
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Iinuma Munekazu
Dep. Of Bioactive Molecules Pharmacognosy Gifu Pharmaceutical Univ.
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Iinuma M
Gifu Pharmaceutical University
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Iinuma M
城西大学薬学部
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OKU Hisae
School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women's University
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石黒 京子
武庫川女子大学生薬学研究室
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Oku H
School Of Pharmaceutical Sciences Mukogawa Women's University
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Oku Hisae
School Of Pharmaceutical Sciences Mukogawa Women 's University
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ISHIGURO Kyoko
School of Pharmaceutical Sciences, Mukogawa Women's University
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Okamura Haruki
兵庫医科大学 病理学第一講座
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UEDA Yoshimi
School of Pharmaceutical Sciences, Mukogawa Women's University
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Ueda Yoshimi
School Of Pharmaceutical Sciences Mukogawa Women's University
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Ishiguro Kyoko
School Of Pharmacy And Pharmaceutical Sciences Mukogawa Women's Univ.
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石黒 京子
Mukogawa Women's Univ. Nishinomiya Jpn
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石黒 京子
武庫川女子大学 薬
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Ishiguro Kyoko
Faculty Of Pharmaceutical Sciences Mukogawa Women's University:pharmaceutical Research Center K
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Ishiguro Kyoko
School Of Pharmaceutical Sciences Mukogawa Women 's University
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Iinuma Munekazu
Gifu Prefectural Institute Of Health And Environment
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Oku Hisae
武庫川女子大学 薬学研究科
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Ito K
Faculty Of Pharmaceutical Sciences Mukogawa Women's University:pharmaceutical Research Center K
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Ueda Y
Showa Coll. Pharmaceutical Sci. Tokyo Jpn
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Iinuma Munekazu
Gifu Pharmaceutical Univ.gifu Jpn
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