Growth Inhibition of Stilbenoids in Welwitschiaceae and Gnetaceae through Induction of Apoptosis in Human Leukemia HL60 Cells(Molecular and Cell Biology)

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概要

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• Fifty-six stilbenoids isolated from the families of Welwitschiaceae and Gnetaceae were screened for growth inhibitory activity against HL60 cells, and two compounds (gnemonol G and gnetin I) among them exhibited a strong activity with IC_<50> of 10.0μM and 12.2μM at 48h incubation, respectively. The growth suppression by gnemonol G and gnetin I was found to be in part due to apoptosis which was assessed by morphological findings such as nuclear condensation and fragmentation, and DNA ladder formation in human leukemia HL60 cells.

• 公益社団法人日本薬学会の論文
• 2006-07-01

著者

• IINUMA Munekazu

  Gifu Pharmaceutical University

• 田中 利男

  帝人株式会社 医薬岩国製造所

• MURATA Hiroko

  Faculty of Pharmaceutical Sciences,Setsunan University

• TANAKA Toshiyuki

  Gifu Prefectural Institute of Health and Environmental Sciences

• ILIYA Ibrahim

  Gifu Pharmaceutical University

• Iinuma Munekazu

  Dep. Of Bioactive Molecules Pharmacognosy Gifu Pharmaceutical Univ.

• Iinuma M

  Gifu Pharmaceutical University

• Iinuma Munekazu

  岐阜薬科大学

• Iinuma M

  城西大学薬学部

• Tanaka Toshiyuki

  Gifu Pharmaceutical Univ.

• Tanaka T

  Kvushu Univ. Fukuoka Jpn

• Nozawa Yoshinori

  Gifu International Institute of Biotechnology

• Murata Hiroko

  東海大学 農学研究科

• Tanaka T

  Osaka Univ. Osaka Jpn

• AKAO Yukihiro

  Gifu International Institute of Biotechnology

• NAKAGAWA Yoshihito

  Gifu International Institute of Biotechnology

• Okano M

  Kitasato Univ. Sagamihara Jpn

• 大村 三男

  Fruit Tree Research Station

• Ito Tetsuro

  Gifu Prefectural Institute of Health and Environmental Sciences

• Ito Tetsuro

  Laboratory of Pharmacognosy, Gifu Pharmaceutical University

• Oyama Masayoshi

  Laboratory of Pharmacognosy, Gifu Pharmaceutical University

• Ito T

  Dep. Of Bioactive Molecules Pharmacognosy Gifu Pharmaceutical Univ.

• Omura M

  Okitsu Branch Fruit Tree Research Station Ministry Of Agriculture Forestry And Fisheries

• Omura Mitsuo

  Faculty Of Pharmacy Meijo University

• Akao Y

  Gifu International Institute Of Biotechnology

• Ohtani Mikinobu

  Department Of Urology Instiute Of Clinical Medicine University Of Tsukuba

• Nozawa Y

  Gifu International Institute Of Biotechnology

• Murata Hiroko

  Faculty Of Human Life Science Osaka City University

• MATSUMOTO Kenji

  Gifu International Institute of Biotechnology

• Iliya I

  Gifu Pharmaceutical University

• Iliya Ibrahim

  Gifu Pharmaceutical Univ. Gifu Jpn

• Tanaka Toshiyuki

  Gifu Prefectrual Inst. Health And Environmental Sci. Gifu Jpn

• OYAMA Masayoshi

  Gifu Pharmaceutical University

• ALI ZULFIQAR

  Gifu Pharmaceutical University

• Iinuma Munekazu

  Gifu Prefectural Institute Of Health And Environment

• Iinuma Munekazu

  Gifu Prefectural Institute Of Health And Environmental Sciences

• Araki Yoko

  Nagaragawa Res. Center Api Co. Ltd.

• Araki Yoko

  Nagaragawa Research Center Api Co. Ltd.

• ZULFIQAR Ali

  Gifu Pharmaceutical University

• Haramoto Mari

  Graduate School Of Comprehensive Scientific Research Program In Biological System Sciences Prefectur

• Murata H

  Okayama Univ. Okayama Jpn

• Onozawa Mizuki

  Cancer Prevenition Division National Cancer Center Research Instiute

• Matsumoto K

  Gifu International Institute Of Biotechnology

• Matsumoto Keiji

  Department Of Orthopaedic Surgery Shiga University Of Medical Science

• Murata Hiroko

  Division Of Virology Department Of Infectious Diseases Osaka Prefectural Institute Of Public Health

• Ohyama M

  Cancer Prevenition Division National Cancer Center Research Instiute

• Tanaka Toshiyuki

  Gifu Pharmaceutical University

• 田中 徹明

  Osaka Univ. Osaka Jpn

• Ito Tetsuro

  Department Of Bioactive Molecutes Pharmacognosy Gifu Pharmaceutical University

• Ito T

  Gifu Prefectrual Inst. Health And Environmental Sci. Kakamigahara Jpn

• Iinuma Munekazu

  Gifu Pharmaceutical Univ.gifu Jpn

• Matsumoto K

  Central Research Laboratory Hitachi Ltd.

• Tanaka Terumichi

  Division Of Bioscience And Biotechnology Department Of Ecological Engineering Toyohashi University O

• Maruyama Hiroe

  Nagaragawa Research Center Api Company Limited

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