Isolation of Apoptosis- and Differentiation-Inducing Substances toward Human Promyelocytic Leukemia HL-60 Cells from Leaves of Juniperus taxifolia
スポンサーリンク
概要
- 論文の詳細を見る
A chloroform extract of the leaves of Juniperas taxifolia exhibited a marked antiproliferative effect on human promyelocytic leukemia HL-60 cells at a concentration of 2.5 μg/ml. Deoxypodophyllotoxin (4) was identified in the extract as an outstanding antiproliferative compound, and five diterpenes (1–3, 5, and 6) were isolated as known compounds with weak or no cytotoxicity. These compounds were examined for their respective apoptosis- and differentiation-inducing activities toward HL-60 cells by DNA fragmentation and NBT-reducing assays, respectively. Among them, 7α-hydroxysandaracopimaric acid (6) was found to have a potent differentiation-inducing activity in a dose-dependent manner at 0.125–2 μg/ml (0.39–6.29 μM), together with apoptosis-inducing activity at concentrations of more than 2.5 μg/ml (7.86 μM). Deoxypodophyllotoxin (4) that exerted cytotoxic and apoptosis-inducing activities at 2 ng/ml (5 nM) did not induce differentiation at the same concentration, and the other diterpenes (1–3 and 5) showed no effect on cell differentiation, even at 5 μg/ml. It was thus demonstrated for the first time that 7α-hydroxysandaracopimaric acid was an effective differentiation-inducing compound toward HL-60 cells.
- 社団法人 日本農芸化学会の論文
著者
-
Tatemoto Hideki
Faculty Of Agriculture University Of The Ryukyus
-
NAKANISHI Tsutomu
Faculty of Pharmaceutical Sciences,Setsunan University
-
INADA Akira
Faculty of Pharmaceutical Sciences,Setsunan University
-
MURATA Hiroko
Faculty of Pharmaceutical Sciences,Setsunan University
-
INATOMI Yuka
Faculty of Pharmaceutical Sciences,Setsunan University
-
Muto Norio
Faculty Of Life And Environmental Sciences Prefectural University Of Hiroshima
-
Tomokuni Tatsuru
School of Bioresources, Hiroshima Prefectural University
-
Haramoto Mari
Faculty of Life and Environmental Sciences, Prefectural University of Hiroshima
関連論文
- Growth and Quality of Radish Sprouts Cultivated in Electrolyzed Acid and Alkaline Solutions
- Tannins and Related Polyphenols,HIV Reverse Transcriptase Inhibitors, from Rosa woodsii
- Flavonol Glycosides in Leaves of Two Diospyros Species
- Essential Role of Ascorbic Acid in Neural Differentiation and Development : High Levels of Ascorbic Acid 2-Glucoside Effectively Enhance Nerve Growth Factor-Induced Neurite Formation and Elongation in PC12 Cells
- Potentiation of Nerve Growth Factor-Induced Neurite Outgrowth in PC12 Cells by a Coptidis Rhizoma Extract and Protoberberine Alkaloids(Biochemistry & Molecular Biology)
- Characteristics of Okinawan Native Agu Pig Spermatozoa After Addition of Low-Density Lipoprotein to Freezing Extender
- Antihyaluronidase Action of Ellagic Acid Effectively Prevents Polyspermy As a Result of Suppression of the Acrosome Reaction Induced by Sperm-Zona Interaction During In Vitro Fertilization of Porcine Oocytes
- Determination of Acrosomal Proteolytic Activity in Spermatozoa Collected from Quail Treated with Diethylstilbestrol, Using Gelatin-Substrate Slide Technique
- Effects of Diethylstilbestrol Administration on Sperm Penetration into the Inner Perivitelline Layer of Japanese Quail, Coturnix japonica
- In vitro formation of holes on the inner perivitelline layer of quail ovum by chicken spermatozoa
- Beyerane Derivatives and a Sesquiterpene Dimer from Japanese Cypress : Chamaecyparis obtusa
- Effects of Wearing Compression Stockings on Cardiovascular Responses
- Anti-HIV-1 Activity of Herbs in Labiatae
- Resin glycosides from the leaves and stems of Ipomoea digitata
- ALTERATION IN GASTRIC MUCOSAL ACID PROTEASE ACTIVITY INDUCED BY NECROTIZING AGENTS AND PREVENTION BY PROSTAGLANDIN E_2
- EFFECTS OF GASTROINTESTINAL HORMONES AND THEIR RELATED COMPOUNDS ON GASTRIC MOTILITY IN THE RAT
- ROLE OF ADRENERGIC AGONISTS ON GASTRIC SECRETION IN THE RAT
- Neurite Outgrowth-Promoting Active Constituents of the Japanese Cypress (Chamaecyparis obtusa)
- New Diarylheptanoids from Alnus japonica and Their Antioxidative Activity
- Isolation of Apoptosis- and Differentiation-Inducing Substances toward Human Promyelocytic Leukemia HL-60 Cells from Leaves of Juniperus taxifolia
- Physiological Role of Ascorbic Acid Secretion System in the Stomach (Proceedings of the 23rd Symposium on Toxicology and Environmental Health)
- 3C-06 Hepatoprotection by zinc and sakuraso-saponin in metallothionein-deficient mice
- 3C-05 Molecular Mechanism of Activation of Mouse Metallothionein-I Promoter by Interleukin-6 and Glucocorticoid
- BINDING OF Cd TO METALLOTHIONEIN IN THE PLACENTA OF Cd-TREATED MOUSE
- Application of Supercritical CO_2 Bubbling to Deodorizing of Drinking Water
- Isolation and Identification of Hydroquinone in Baker's Yeast(Biological Chemistry)
- A Monoterpene Glucoside and Three Megastigmane Glycosides from Juniperus communis var. depressa
- Inhibitory Effect of Plant Extracts on Production of Verotoxin by Enterohemorrhagic Escherichia coil O157 : H7
- A new amide from the leaves and twigs of Litsea auriculata
- Triterpenes and Flavonol Glucuronides from Oenothera cheiranthifolia
- Phytochemical Study on American Plants I. Two New Phenol Glucosides, together with Known Biflavones and Diterpene, from Leaves of Juniperus occidentalis HOOK.
- New Hydrolyzable Tannins, Shephagenins A and B, from Shepherdia argentea as HIV-1 Reverse Transcriptase Inhibitors
- Cancer Chemopreventive Activity of Odorine and Odorinol from Aglaia odorata
- A New and Known Cytotoxic Aryltetralin-Type Lignans from Stems of Bursera graveolens
- A Cytological Analysis of 24 Taxa in Aristolochia Subgenera Siphisia and Aristolochia (Aristolochiaceae)
- Highly Polarized Electron Source Using InGaAs-GaAs Strained-Layer Superlattice
- Growth Inhibition of Stilbenoids in Welwitschiaceae and Gnetaceae through Induction of Apoptosis in Human Leukemia HL60 Cells(Molecular and Cell Biology)
- New Phenylpropanoid Glycosides from Juniperus communis var. depressa
- Three New Furoquinoline Alkaloids from the Leaves of Boninia glabra
- Cancer Chemopreventive Activity of 2-(2, 3, 6-Trihydroxy-4-carboxyphenyl) ellagic Acid from the Fruits of Casealpinia ferrea
- A New Eudesmane Sesquiterpene from the Twigs of Aglaia grandis
- Antibacterial Activity of Extracts Prepared from Tropical and Subtropical Plants on Methicillin-Resistant Staphylococcus aureus
- Diamide Derivatives and Cycloartanes from the Leaves of Aglaia elliptica
- Constituents of a Fern, Diplazium subsinuatum. III. Four New Hopane-Triterpene Lactone Glycosides
- Constituents of a Fern, Diplazium subsinuatum. II. Structure Elucidation of Five New Hopane-Triterpene Glycosides
- Manufacture and Performance of Cylindrical Gears : An Application of New Finish-Hobs for Increasing Surface Durability
- Load-Carrying Capacity of HB≃340 (Hardened and Tempered) Gears : Influence of Gear Ratio and Surface Roughness on Surface Durability
- Load-Carrying Capacity of Surface-Hardened Gears : Influence of Surface Roughness on Surface Durability : Vibration, Control Engineering, Engineering for Industry
- Manufacture and Performance of Spheroidal Graphite Cast lron Gears : 2nd Report, Load-carrying Capacities of As-cast FCD 70〜80 Gears
- Manufacturing and Performance of Spheroidal Graphite Cast lron Gear : 1st Report, An Application to Medium-hardness Gears
- Effects of Tooth Form on Stresses in Helical Gears : 1st Report, Effects of Convex and Concave Tooth Profiles
- Load-carrying Capacity of the HB〓340 (Hardened and Tempered) Gears : 4th Report, Effect of Surface-finishing on Surface Durability
- Load-carrying Capacity of the HB〓340 (Hardened and Tempered) Gears : 3rd Report, Influences of Difference in Hardness and Roughness on Surface Drability
- Load-carrying Capacity of the HB〓340 (Hardened and Tempered) Gears : 2nd Report, Surface Durabilities of the Leaded Free-cutting Steel Hobbed Gears and Honed Gears
- Load-carrying Capacity of the HB〓340 (Hardened and Tempered) Gears : 1st Report, Effect of Surface Roughness on the Rolling Contact Fatigue of the Rollers and Surface Durability of the Habbed Gears
- Molecular Phylogeny of Aristolochia (Aristolochiaceae) Inferred from matK Sequences
- Molecular Phylogeny of Aucuba (Aucubaceae)
- Isolation of Apoptosis- and Differentiation-Inducing Substances toward Human Promyelocytic Leukemia HL-60 Cells from Leaves of Juniperus taxifolia
- GC-MS Analysis of Organic Compounds in Rain Water (Regular Presentations) (Proceedings of the 9th Symposium on Environmental Pollutants and Toxicology)
- Role of Acidification Elicited by Sialylation and Sulfation of Zona Glycoproteins During Oocyte Maturation in Porcine Sperm-zona Pellucida Interactions
- Iridoid and Flavonol Glycosides from the Leaves of Geniostoma glabrum
- A Fundamental Study of the Surface Durability of Medium-Hardness Gears : Effects of Combination of Hardness and Surface Roughness
- ろ紙クロマトグラフィーにより食用青色1号(ブリリアントブルーFCF)アルミニウムレーキから検出された付随色素の構造
- Tannins and Related Polyphenols, HIV Reverse Transcriptase Inhibitors, from Rosa woodsii(Natural Medicine Note)
- A New Eudesmane Sesquiterpene from the Twigs of Aglaia grandis
- Phytochemical Studies on Meliaceous Plants. XIII. : Structures of Constituents of Leaves of Aglaia odorata and Their Inhibitory Effects on Epstein-Barr Virus Activation
- Cancer Chemopreventive Activity of 2-(2,3,6-Trihydroxy-4-carboxyphenyl)ellagic Acid from the Fruits of Caesalpinia ferrea
- Inhibitory Effects of Bufadienolides on Epstein-Barr Virus Early Antigen Activation and on Growth of Mouse Skin and Mouse Pulmonary Tumors
- Screening of Anti-HIV-1 Activity of North American Plants. : Anti-HIV-1 Activities of Plant extracts, and Active Components of Lethalia vulpina (L.) Hue.
- Studies on Inhibitors of Skin Tumor Promotion. VII. : Inhibitory Effects of Steroids on Epstein-Barr Virus Activation
- Phytochemical Studies of Seeds of Medicinal Plants IV : Flavonoids and Triterpenoids from Patrinia villosa (THUNB.) Juss.
- Antiviral and Antitumour Activities of Some Western North American Plants with Surface Exudates (1) : Inhibitory Effects on HIV-1 Reverse Transcriptase
- Pseudo-ginsenoside-RP_1 and Zingibroside-R_1 from Seeds of Strongylodon macrobotrys A. GRAY
- Studies on Inhibitors of Skin Tumor Promotion (V) : Inhibitory Effects of Flavonoids on Epstein-Barr Virus Activation. II.
- Screening of Anti-HIV-1 Activity of North American Plants. Anti-HIV-1 Activities of Plant extracts, and Active Components of Lethalia vulpina (L.) Hue
- Role of Acidification Elicited by Sialylation and Sulfation of Zona Glycoproteins During Oocyte Maturation in Porcine Sperm-zona Pellucida Interactions
- 7-Ketologanin, an Iridoid Glucoside from Fruits of Strychnos roborans A. W. HILL
- Effects of Fluid Secreted from the Uterus on Duration of Fertile Egg Production in Hens, and Survivability and Penetrability of Fowl Sperm in vitro