Antiviral and Antitumour Activities of Some Western North American Plants with Surface Exudates (1) : Inhibitory Effects on HIV-1 Reverse Transcriptase
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概要
- 論文の詳細を見る
Acetone, ethanol and/or warm 70% aqueous ethanol extracts of three lichen species and 83 species of higher plants (1 Pteridophyte and 82 Spermatophytes) from SW Oregon and NW California were tested for their inhibitory effects on HIV-1 reverse transcriptase. The inhibitory effect of each extract was determined in a reaction mixture containing (rA)_n・(dT)_<12-18> as the template. primer and [^3H]dTTP as the triphosphate substrate, under optimized reaction conditions for HIV-1 reverse transcriptase. Fifty four species showed significant inhibitory effects in this in vitro screening test. Ethanol extracts of Polygonum majus (whole plant), Purshia tridentata (stems), Potentilla gracilis (underground parts), Ceanothus integerrimus (stems), Arctostaphylos viscida (aerial parts) and Grindelia nana (whole plant) showed more than 20% inhibition at 0.5 μg/ml concentration. It seemed surprising that 70 % of the secretory plants (32 out of 46 samples) showed the inhibitory activity.
- 日本生薬学会の論文
- 1993-09-20
著者
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Murata Jin
Botanical Gardens Koishikawa Graduate School Of Sci. The Univ. Of Tokyo
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NAKANISHI Tsutomu
Faculty of Pharmaceutical Sciences,Setsunan University
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水野 瑞夫
岐阜薬科大学
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水野 瑞夫
Gifu Pharmaceutical University
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Nagase Hidetaka
Pharmacobioregulation Research Laboratory Taiho Pharmaceutical Co. Ltd.
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Tanaka Toshiyuki
Gifu Pharmaceutical Univ.
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Nagase Hisamitsu
Laboratory Of Hygienic Chemistry And Molecular Toxicology Gifu Pharmaceutical University
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Nagase Hisamitsu
岐阜薬科大学 公衆衛
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NAGASE Hisamitsu
Dept.Public Health, Gifu Pharmaceutical University
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Lang Frank
Dep. Of Biology Southern Oregon Univ.
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Nagase Hisamitsu
Lab. Of Hygienic Chemistry And Molecular Toxicology Gifu Pharmaceutical Univ.
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Mizuno Mizuo
Gifu Pharmaceutical Univercity
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Lang Frank
Department Of Biology Southern Oregon State College
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Ono Katsuhiko
Laboratory Of Oncology Aichi Cancer Center Research Institute
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Murata Hiroko
Faculty Of Human Life Science Osaka City University
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Nakane Hideo
Laboratory Of Viral Oncology Aichi Cancer Center Research Institute
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Murata Jin
Botanical Garden Graduate School Of Science University Of Tokyo
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Inada Akira
Faculty Of Pharmaceutical Sciences Setsunan University
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Mizuno M
Gifu Pharmaceutical Univ. Gifu Jpn
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Murata H
Okayama Univ. Okayama Jpn
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Murata Hiroko
Division Of Virology Department Of Infectious Diseases Osaka Prefectural Institute Of Public Health
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Ono Katsuhiko
Laboratory Of Neural Information National Institute For Physiological Sciences Okazaki National Rese
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YAMAMOTO Hirobumi
Gifu Pharmaceutical University
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Murata J
Botanical Gardens Graduate School Of Sciences The University Of Tokyo
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Iinuma Munekazu
Gifu Pharmaceutical Univ.gifu Jpn
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KATO MASAYA
Gifu Pharmaceutical University
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Nakanishi Tsutomu
Faculty Of Pharmaceutical Sciences Setsunan University
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Nakanishi Tsutomu
Faculty Of Engineering Miyazaki University
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MIZUNO MIZUO
Gifu College of Pharmacy
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