Inhibitory Effects of Bufadienolides on Epstein-Barr Virus Early Antigen Activation and on Growth of Mouse Skin and Mouse Pulmonary Tumors

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概要

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• Bufalin and resibufogenin showed the potent inhibitory activities on Epstein-Barr virus early antigen activation, induced by 12-O-tetradecanoylphorbol-13-acetate(TPA), as an in vitro screening test for anti-tumor promoting agents. Further, bufalin inhibited in vivo two-stage carcinogenesis tests of mouse skin papillomas induced by 7,12-dimethylbenz[a]anthracene and TPA, and mouse pulmonary tumors induced by 4-nitroquinoline-N-oxide and glycerol.

• 1999-12-20

著者

• NAKANISHI Tsutomu

  Faculty of Pharmaceutical Sciences,Setsunan University

• Okano M

  Kitasato Univ. Sagamihara Jpn

• 大村 三男

  Fruit Tree Research Station

• Oyama Masayoshi

  Laboratory of Pharmacognosy, Gifu Pharmaceutical University

• Omura M

  Okitsu Branch Fruit Tree Research Station Ministry Of Agriculture Forestry And Fisheries

• Omura Mitsuo

  Faculty Of Pharmacy Meijo University

• Nishino H

  Toho University School Of Pharmaceutical Sciences

• Nishino H

  Department Of Biochemistry And Molecular Biology Kyoto Prefectural University Of Medicine

• Nishino Hoyoku

  Kyoto Prefectural University Of Medicine

• Ohtani Mikinobu

  Department Of Urology Instiute Of Clinical Medicine University Of Tsukuba

• MUKAINAKA Teruo

  Kyoto Prefectural University of Medicine

• OKUDA Masato

  Kyoto Prefectural University of Medicine

• TOKUDA Harukuni

  Kyoto Prefectural University of Medicine

• Iwashima Akio

  Kyoto Prefectural University of Medicine

• Inada A

  Fac. Of Pharmaceutical Sciences Setsunan Univ.

• Tokuda Harukuni

  Dep. Of Complementary And Alternative Medicine Clinical R&d Graduate School Of Medical Sci. Kana

• Tokuda H

  Department Of Biochemistry Kyoto Prefectural University Of Medicine

• Tokuda Harukuni

  Department Of Microbiology Faculty Of Medicine Kyoto University

• Tokuda Harukuni

  Department Of Biochemistry Kyoto Prefectural University Of Medicine

• Inada Akira

  Faculty Of Pharmaceutical Sciences Setsunan University

• Okuda M

  Fujitsu Lab. Ltd. Kawasaki‐shi Jpn

• Onozawa Mizuki

  Cancer Prevenition Division National Cancer Center Research Instiute

• Nakanishi T

  Graduate School Of Science Nagoya University

• Ohyama M

  Cancer Prevenition Division National Cancer Center Research Instiute

• Ichiishi Eiichiro

  Kyoto Prefectural University Of Medicine

• Nakanishi T

  Fac. Of Pharmaceutical Sciences Setsunan Univ.

• Muranaka Takashi

  Faculty Of Pharmaceutical Sciences Okayama University

• Nakanishi Tsutomu

  Faculty Of Pharmaceutical Sciences Setsunan University

• Nakanishi Tsutomu

  Faculty Of Engineering Miyazaki University

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