Cancer Chemopreventive Activity of Odorine and Odorinol from Aglaia odorata

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概要

• 論文の詳細を見る

• In the course of our continuing search for novel cancer chemo-preventive agents from natural sources, we have carried out a primary screening in vitro assay of the compounds isolated from Aglaia odorata. Consequently, aminopyrrolidine-diamides, odorine and odorinol, were obtained as active constituents. These compounds exhibited potent anti-carcinogenic effects in a two-stage carcinogenesis test of mouse skin induced by 7, 12-dimethyl-benz[a]anthracene (DMBA) as an initiator and 12-O-tetradecanoylphorbol-13-acetate (TPA) as a promoter. Further, both compounds showed remarkable inhibitory effects in two-stage mouse skin carcinogenesis models induced by nitric oxide (NO) donors such as (±)-(E)-methyl-2-[(E)-hydroxyimino]-5-nitro-6-methoxy-3-hexenamide (NOR-1) or peroxynitrite as an initiator and TPA as a promoter. From these results, it was concluded that odorine and odorinol inhibited both the initiation and promotion stages of two-stage skin carcinogenesis.

• 公益社団法人日本薬学会の論文
• 2001-11-01

著者

• INADA Akira

  Faculty of Pharmaceutical Sciences,Setsunan University

• Okano M

  Kitasato Univ. Sagamihara Jpn

• 大村 三男

  Fruit Tree Research Station

• Oyama Masayoshi

  Laboratory of Pharmacognosy, Gifu Pharmaceutical University

• Omura M

  Okitsu Branch Fruit Tree Research Station Ministry Of Agriculture Forestry And Fisheries

• Omura Mitsuo

  Faculty Of Pharmacy Meijo University

• Nishino H

  Toho University School Of Pharmaceutical Sciences

• Nishino H

  Department Of Biochemistry And Molecular Biology Kyoto Prefectural University Of Medicine

• Nishino Hoyoku

  Kyoto Prefectural University Of Medicine

• Ohtani Mikinobu

  Department Of Urology Instiute Of Clinical Medicine University Of Tsukuba

• KUCHIDE Masashi

  Department of Biochemistry, Kyoto Prefecture! University

• KUCHIDE Masashi

  Kyoto Prefectural University of Medicine

• TAKAYASU Junko

  Kyoto Prefectural University of Medicine

• MUKAINAKA Teruo

  Kyoto Prefectural University of Medicine

• NOBUKUNI Yoshitaka

  Kyoto Prefectural University of Medicine

• OKUDA Masato

  Kyoto Prefectural University of Medicine

• TOKUDA Harukuni

  Kyoto Prefectural University of Medicine

• Iwashima Akio

  Kyoto Prefectural University of Medicine

• Mukainaka T

  Kyoto Prefectural University Of Medicine

• Inada A

  Fac. Of Pharmaceutical Sciences Setsunan Univ.

• Tokuda Harukuni

  Dep. Of Complementary And Alternative Medicine Clinical R&d Graduate School Of Medical Sci. Kana

• Inada Akira

  Faculty Of Pharmaceutical Sciences Setsunan University

• Onozawa Mizuki

  Cancer Prevenition Division National Cancer Center Research Instiute

• Ohyama M

  Cancer Prevenition Division National Cancer Center Research Instiute

• Nobukuni Y

  Kyoto Prefectural University Of Medicine

• Muranaka Takashi

  Faculty Of Pharmaceutical Sciences Okayama University

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