Laxative Effect of Agarwood Leaves and Its Mechanism

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概要

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• We investigated the laxative activity of an extract of agarwood leaves from Aquilaria sinensis. The laxative activity was measured in mice by counting the stool frequency and stool weight, and the drugs were orally administered. An acetone extract of agarwood leaves and senna (a representative laxative drug) both increased the stool frequency and weight, but a methanol extract did not. The laxative effect of the acetone extract was milder than that of the anthraquinoid laxative, senna, and the former did not induce diarrhea as a severe side effect. We identified the main constituent contributing to the laxative effect of the acetone extract as genkwanin 5-O-β-primeveroside (compound 4). Compound 4 strengthened the spontaneous motility and induced contraction in the ileum. This ileal contraction induced by compound 4 was inhibited by atropine, but not by azasetron, suggesting that the effect of compound 4 was mediated by acetylcholine receptors, and not by serotonin. The laxative mechanism for compound 4 may in part involve stimulation of intestinal motility via acetylcholine receptors.

• 社団法人 日本農芸化学会の論文
• 2008-02-23

著者

• Iinuma Munekazu

  岐阜薬科大学

• Iinuma M

  城西大学薬学部

• Hara Hideaki

  Dep. Of Biofunctional Evaluation Molecular Pharmacology Gifu Pharmaceutical Univ.

• Hara Hideaki

  Department Of Biofunctional Evaluation Molecular Pharmacology Gifu Pharmaceutical University

• SHIMAZAWA Masamitsu

  Department of Biofunctional Evaluation, Molecular Pharmacology, Gifu Pharmaceutical University

• 大村 三男

  Fruit Tree Research Station

• Ohyama Masayoshi

  Department of Pharmacognosy,Gifu Pharmaceutical University

• Ohyama M

  Cancer Prevenition Division National Cancer Center Research Instiute

• Ise Yasuaki

  Department Of Bioactive Molecules Pharmacognosy Gifu Pharmaceutical University

• Iinuma Munekazu

  Department Of Bioactive Molecutes Pharmacognosy Gifu Pharmaceutical University

• MORIMOTO Nobutaka

  Department of Biofunctional Evaluation, Molecular Pharmacology, Gifu Pharmaceutical University

• ICHIHASHI Koji

  Department of Bioactive Molecules, Pharmacognosy, Gifu Pharmaceutical University

• Shimazawa Masamitsu

  Molecular Pharmacology Dep. Of Biofunctional Evaluation Gifu Pharmaceutical Univ. Jpn

• Shimazawa Masamitsu

  Department Of Biofunctional Evaluation Molecular Pharmacology Gifu Pharmaceutical University

• Ichihashi Koji

  Department Of Bioactive Molecules Pharmacognosy Gifu Pharmaceutical University

• Morimoto Nobutaka

  Department Of Biofunctional Evaluation Molecular Pharmacology Gifu Pharmaceutical University

• Oyama Masayoshi

  Department Of Bioactive Molecutes Pharmacognosy Gifu Pharmaceutical University

• IINUMA Munekazu

  Department of Bioactive Molecules, Pharmacognosy, Gifu Pharmaceutical University

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