Effects of Sesquiterpene Lactones on Melanogenesis in Mouse B16 Melanoma Cells(Biopharmacy)
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概要
- 論文の詳細を見る
In this study, we examined the effect of sesquiterpene lactones isolated from Calea urticifolia and Tanacetum parthenium (feverfew) on melanogenesis in mouse B16 melanoma cells. In response to 3-isobutyl-1-methylxanthin (IBMX), B16 melanoma cells underwent differentiation characterized by increased melanin biosynthesis. Treatment of sesquiterpene lactones at lower concentration (1μM) significantly blocked IBMX-induced melanogenesis, but did not induce the inhibitory activity of cell growth. Among them, 2,3-epoxyjuanislamin exhibited a potent inhibitory effect on melanogenesis. Treatment of B16 cells with 2,3-epoxyjuanislamin elicited significant decreases in tyrosinase protein and mRNA levels. These results demonstrated that the inhibitory effects of sesquiterpene lactones on melanin biosynthesis may be due to the suppression of tyrosinase expression.
- 2009-02-01
著者
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IINUMA Munekazu
Gifu Pharmaceutical University
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Iinuma Munekazu
Dep. Of Bioactive Molecules Pharmacognosy Gifu Pharmaceutical Univ.
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Iinuma M
Gifu Pharmaceutical University
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Iinuma Munekazu
岐阜薬科大学
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Iinuma M
城西大学薬学部
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Nozawa Yoshinori
Gifu International Institute of Biotechnology
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Ohguchi Kenji
Gifu International Institute of Biotechnology
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AKAO Yukihiro
Gifu International Institute of Biotechnology
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Akao Y
Gifu International Institute Of Biotechnology
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Nozawa Y
Gifu International Institute Of Biotechnology
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Yokoyama Kouji
Pola Chemical Industries Inc.
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Iinuma Munekazu
Gifu Prefectural Institute Of Health And Environment
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Iinuma Munekazu
Gifu Prefectural Institute Of Health And Environmental Sciences
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Araki Yoko
Nagaragawa Res. Center Api Co. Ltd.
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Araki Yoko
Nagaragawa Research Center Api Co. Ltd.
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Itoh Tomohiro
Gifu International Institute Of Biotechnology
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ITO Masaaki
Pola Chemical Industries, Inc.
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Iinuma Munekazu
Gifu Pharmaceutical Univ.gifu Jpn
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Ito Masaaki
Pola Chemical Industries Inc.
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