Melanogenesis Stimulation in Murine B16 Melanoma Cells by Kava (Piper methysticum) Rhizome Extract and Kavalactones(Pharmacognosy)
スポンサーリンク
概要
- 論文の詳細を見る
Melanogenesis stimulation activity of aqueous ethanolic extracts obtained from several different parts of five Piper species, namely Piper longum, P. kadsura, P. methysticum, P. betle, and P. cubeba, were examined by using cultured murine B16 melanoma cells. Among them, the extract of P. methysticum rhizome (Kava) showed potent stimulatory effect on melanogenesis as well as P. nigrum leaf extract. Activity-guided fractionation of Kava extract led to the isolation of two active kavalactones, yangonin (2) and 7, 8-epoxyyangonin (5), along with three inactive kavalactones, 5, 6-dehydrokawain (1), (+)-kawain (3) and (+)-methysticin (4), and a glucosylsterol, daucosterin (6). 7, 8-Epoxyyangonin (5) showed a significant stimulatory effect on melanogenesis in B16 melanoma cells. Yangonin (2) exhibited a weak melanogenesis stimulation activity.
- 公益社団法人日本薬学会の論文
- 2006-04-01
著者
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HIRATA Noriko
School of Pharmacy, Kinki University
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IINUMA Munekazu
Gifu Pharmaceutical University
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MATSUDA Hideaki
School of Pharmacy, Kinki University
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NARUTO Shunsuke
School of Pharmacy, Kinki University
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田中 利男
帝人株式会社 医薬岩国製造所
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Iinuma Munekazu
Dep. Of Bioactive Molecules Pharmacognosy Gifu Pharmaceutical Univ.
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Iinuma M
Gifu Pharmaceutical University
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Iinuma Munekazu
岐阜薬科大学
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Iinuma M
城西大学薬学部
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Tanaka Toshiyuki
Gifu Pharmaceutical Univ.
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Mitani Hidetsugu
三重大学 第2内科
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Tanaka T
Kvushu Univ. Fukuoka Jpn
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角谷 真
京都薬科大学
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Tanaka T
Osaka Univ. Osaka Jpn
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KUBO Michinori
School of Pharmaceutical Sciences, Kinki University
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Naruto S
School Of Pharmacy Kinki University
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Naruto Shunsuke
近畿大学 薬学部薬用資源学研究室
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Kubo M
School Of Pharmaceutical Sciences Kinki University
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Kubo Michinori
近畿大学 薬学部
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Hirata N
School Of Pharmacy Kinki University
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Hirata Noriko
Department Of Pharmaceutical Sciences Kinki University
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Kubo Michinori
Kyoto Pharmaceutical University
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Kubo Michinori
School Of Pharmaceutical Sciences Kinki University
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Naruto Shunsuke
School Of Pharmaceutical Sciences Kinki University
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KAWAGUCHI Yoshiko
School of Pharmaceutical Sciences, Kinki University
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Matsuda Hideaki
School Of Pharmacy Kinki University
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Tanaka Toshiyuki
Gifu Prefectrual Inst. Health And Environmental Sci. Gifu Jpn
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Hirata N
3rd Section Of Research And Development Toyo Suisan Kaisha Ltd.
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Hirata Noriko
School Of Pharmacy Kinki University
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TAKATA Takanobu
Gifu Pharmaceutical University
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OYAMA Masayoshi
Gifu Pharmaceutical University
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Iinuma Munekazu
Gifu Prefectural Institute Of Health And Environment
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Iinuma Munekazu
Gifu Prefectural Institute Of Health And Environmental Sciences
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Kawaguchi Yoshiko
School Of Pharmaceutical Sciences Kinki University
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Kubo M
Kampo And Pharmacognosy Laboratory Tsumura And Co.
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Kubo M
Faculty Of Pharmaceutical Sciences Tokushima Bunri University
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Tanaka Toshiyuki
Gifu Pharmaceutical University
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田中 徹明
Osaka Univ. Osaka Jpn
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Iinuma Munekazu
Gifu Pharmaceutical Univ.gifu Jpn
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Tanaka Terumichi
Division Of Bioscience And Biotechnology Department Of Ecological Engineering Toyohashi University O
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MATSUDA Hideaki
School of Pharmaceutical Sciences, Kinki University
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