Inhibitory Effects of Citrus hassaku Extract and Its Flavanone Glycosides on Melanogenesis(Pharmacognosy)
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概要
- 論文の詳細を見る
The 50% ethanolic extract (CH-ext) obtained from the unripe fruit of Citrus hassaku exhibited significant tyrosinase inhibitory activity. The CH-ext showed antioxidant activity, such as superoxide dismutase (SOD)-like activity and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical-scavenging activity. Activity-guided fractionation of the CH-ext indicated that flavanone glycoside-rich fractions showed potent tyrosinase inhibitory activity. Further examination revealed that the tyrosinase inhibitory activity and antioxidant activity of the CH-ext were attributable to naringin and neohesperidin, respectively. The CH-ext showed inhibition of melanogenesis without any effects on cell proliferation in cultured murine B16 melanoma cells after glucosamine exposure. The topical application of the CH-ext to the dorsal skin of brownish guinea pigs showed in vivo preventive effects against UVB-induced pigmentation.
- 社団法人日本薬学会の論文
- 2009-03-01
著者
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MURATA Kazuya
School of Pharmacy, Kinki University
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HIRATA Noriko
School of Pharmacy, Kinki University
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MATSUDA Hideaki
School of Pharmacy, Kinki University
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NARUTO Shunsuke
School of Pharmacy, Kinki University
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ITOH Kimihisa
School of Pharmacy, Kinki University
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松田 秀秋
近畿大学 薬学部
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Itoh Kimihisa
近畿大学 薬学部薬用資源学研究室
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Itoh Kimihisa
近畿大学 農学部
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Itoh Kimihisa
Faculty Of Pharmacy Kinki University
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Itoh Kimihisa
近畿大学 薬学部
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Miwa H
Second Department Of Internal Medicine Mie University School Of Medicine
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Miyashita Hiroyuki
三重大学 医学部内科学第2
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Mitani H
Second Department Of Internal Medicine Mie University School Of Medicine
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Mitani Hidetsugu
Division Of Hematology And Oncology Suzuka General Hospital
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Mitani Hidetsugu
三重大学 第2内科
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Moriyama Kenzo
近畿大学 薬学部
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MASUDA Megumi
School of Pharmacy, Kinki University
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WAKABAYASHI Keitaro
Department of Product Development, Wellco Co., Ltd.
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Naruto S
School Of Pharmacy Kinki University
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Naruto Shunsuke
近畿大学 薬学部薬用資源学研究室
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Murata Kazuya
School Of Pharmacy Kinki University
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Miwa Hiroshi
三重大学 第2内科
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Murata Kazuya
Laboratory Of Natural Drug Resources Faculty Of Pharmacy Kinki University
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Hirata N
School Of Pharmacy Kinki University
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Hirata Noriko
Department Of Pharmaceutical Sciences Kinki University
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Naruto Shunsuke
School Of Pharmaceutical Sciences Kinki University
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Matsuda Hajime
Nihon Shokuhin Kako Co. Ltd.
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Matsuda Hideaki
Laboratory Of Natural Drug Resources Faculty Of Pharmacy Kinki University
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前田 初男
大阪大学大学院薬学研究科分子薬科学専攻
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前田 初男
大阪大学大学院薬学研究科
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Maeda H
Faculty Of Pharmaceutical Sciences Osaka University
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Maeda Hatsuo
Faculty Of Pharmaceutical Sciences Osaka University
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Matsuda Hideaki
School Of Pharmacy Kinki University
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Hirata N
3rd Section Of Research And Development Toyo Suisan Kaisha Ltd.
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Hirata Noriko
School Of Pharmacy Kinki University
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Wakabayashi Keitaro
Department Of Product Development Wellco Co. Ltd.
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Maeda Haruka
The Institute Of Physical And Chemical Research(riken)
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松田 久司
Kyoto Pharmaceutical Univ.
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MATSUDA Hideaki
School of Pharmaceutical Sciences, Kinki University
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