Medicinal Flowers. XXVII : New Flavanone and Chalcone Glycosides, Arenariumosides I, II, III, and IV, and Tumor Necrosis Factor-α Inhibitors from Everlasting, Flowers of Helichrysum arenarium

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概要

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• The methanolic extract from the flowers of Helichrysum arenarium L. MOENCH was found to show inhibitory effect on tumor necrosis factor-α (TNF-α, 1ng/ml)-induced cytotoxicity in L929 cells. From the methanolic extract, 50 constituents including four new flavanone and chalcone glycosides named arenariumosides I (1), II (2), III (3), and IV (4) were isolated. The stereostructures of 1-4 were elucidated on the basis of chemical and physicochemical evidence. Among the constituents, naringenin 7-O-β-D-glucopyranoside (7), apigenin 7-O-β-D-glucopyranoside (14), apigenin 7-O-gentiobioside (16), and apigenin 7,4'-di-O-β-D-glucopyranoside (17) significantly inhibited TNF-α-induced cytotoxicity in L929 cells at 30μM.

• 社団法人日本薬学会の論文
• 2009-04-01

著者

• NAKAMURA Seikou

  Kyoto Pharmaceutical University

• MATSUDA Hisashi

  Kyoto Pharmaceutical University

• 森川 敏生

  Pharmaceutical Res. And Technol. Inst. Kinki Univ.

• 吉川 雅之

  Kyoto Pharmaceutical Univ.

• Morikawa Toshio

  Pharmaceutical Research and Technology Institute, Kinki University

• Ninomiya Kiyofumi

  Pharmaceutical Research and Technology Institute, Kinki University

• Yoshikawa Masayuki

  Pharmaceutical Research and Technology Institute, Kinki University

• Muraoka Osamu

  Pharmaceutical Research and Technology Institute, Kinki University

• WANG Li-Bo

  Kyoto Pharmaceutical University

• YOKOYAMA Eri

  Pharmaceutical Research and Technology Institute, Kinki University

• Wu Li-Jun

  Faculty of Natural Medicines, Shenyang Pharmaceutical University

• 山崎 幹夫

  千葉大学薬学部

• 松田 秀秋

  近畿大学 薬学部

• 山崎 幹夫

  千葉大学薬学部医薬品素材学講座

• Miwa H

  Second Department Of Internal Medicine Mie University School Of Medicine

• Miyashita Hiroyuki

  三重大学 医学部内科学第2

• Wu Lijun

  中華人民共和国

• Muraoka Osamu

  Pharmaceutical Research And Technology Institute Kinki University

• Muraoka Osamu

  近畿大学薬学総合研究所

• Mitani H

  Second Department Of Internal Medicine Mie University School Of Medicine

• Mitani Hidetsugu

  Division Of Hematology And Oncology Suzuka General Hospital

• Mitani Hidetsugu

  三重大学 第2内科

• Yoshikawa M

  Program In Tissue Engineering Department Of Parasitology Nara Medical University

• Wu Li

  School Of Traditional Chinese Materia Medica Shenyang Pharmaceutical University

• Miwa Hiroshi

  三重大学 第2内科

• Wu Lijun

  Department Of Traditional Chinese Medicines Shenyang Pharmaceutical University

• Wu Lijun

  Materials Science Division Brookhaven National Laboratory

• Yamada Eriko

  Pharmaceutical Research And Technology Institute Kinki University

• Yamada E

  Kinki Univ. Osaka Jpn

• Yamazaki Masatoshi

  Faculty Of Pharmaceutical Sciences Teikyo University Sagamiko

• 山田 美紀子

  Faculty Of Pharmaceutical Sciences Chiba University

• Matsuda Hajime

  Nihon Shokuhin Kako Co. Ltd.

• Yamazaki M

  School Of Pharmaceutical Sciences Kinki University

• Matsuda Hideaki

  Laboratory Of Natural Drug Resources Faculty Of Pharmacy Kinki University

• 前田 初男

  大阪大学大学院薬学研究科分子薬科学専攻

• 前田 初男

  大阪大学大学院薬学研究科

• Maeda H

  Faculty Of Pharmaceutical Sciences Osaka University

• Maeda Hatsuo

  Faculty Of Pharmaceutical Sciences Osaka University

• Morikawa Toshio

  Pharmaceutical Research And Technology Institute Kinki University

• Wu Li-jun

  School Of Traditional Chinese Materia Medica Shenyang Pharmaceutical University

• Wang Li-bo

  Kyoto Pharmaceutical University:faculty Of Natural Medicines Shenyang Pharmaceutical University

• Muraoka Osamu

  Pharmaceutical Res. And Technol. Inst. Kinki Univ.

• Morikawa T

  Research Institute Fuji Chemical Industries Ltd.

• Maeda Haruka

  The Institute Of Physical And Chemical Research(riken)

• 松田 久司

  Kyoto Pharmaceutical Univ.

• Wu Lijun

  School Of Traditional Chinese Materia Medica Shenyang Pharmaceutical University

• Wu Li-jun

  Faculty Of Natural Medicines Shenyang Pharmaceutical University

• Nakamura Seikou

  Department Of Applied Biology Kyoto Institute Of Technology

• Nakatani K

  Pharmaceutical Res. And Technol. Inst. Kinki Univ.

• Nakamura Seikou

  Department of Applied Biology, Kyoto Institute of Technology

• MATSUDA HISASHI

  Kyoto College of Pharmacy

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