Medicinal Flowers. XV. The Structures of Noroleanane- and Oleanane-Type Triterpene Oligoglycosides with Gastroprotective and Platelet Aggregation Activities from Flower Buds of Camellia japonica
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概要
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The methanolic extract from the flowers buds of Camellia japonica L. (Theaceae) were found to exhibit potent inhibitory activities on ethanol- or indomethacin-induced gastric mucosal lesions in rats. Through bioassayguided separation, 28-noroleanane-type triterpene Oligoglycosides, camelliosides A, B, and C, and an oleanane-type triterpene oligoglycoside, camellioside D, were isolated from the methanolic extract together with five known compounds. The absolute stereostructures of camelliosides were determined on the basis of chemical and physicochemical evidence, which included the structure revision of the nortriterpene aglycons (camellenodiol and camelledionol). The principal Oligoglycosides, camelliosides A and B, showed platelet aggregation activity in addition to the gastroprotective effects on ethanol- or indomethacin-induced gastric mucosal lesions in rats.
- 公益社団法人日本薬学会の論文
- 2007-04-01
著者
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NAKAMURA Seikou
Kyoto Pharmaceutical University
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MATSUDA Hisashi
Kyoto Pharmaceutical University
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YOSHIKAWA Masayuki
Kyoto Pharmaceutical University
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Morikawa Toshio
Kyoto Pharmaceutical University
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森川 敏生
Pharmaceutical Res. And Technol. Inst. Kinki Univ.
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吉川 雅之
Kyoto Pharmaceutical Univ.
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ASAO Yasunobu
Kyoto Pharmaceutical University
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山崎 幹夫
千葉大学薬学部
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松田 秀秋
近畿大学 薬学部
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Miyashita Hiroyuki
三重大学 医学部内科学第2
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Mitani Hidetsugu
三重大学 第2内科
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Yamazaki M
School Of Pharmaceutical Sciences Kinki University
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前田 初男
大阪大学大学院薬学研究科分子薬科学専攻
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Asao Y
Kyoto Pharmaceutical University
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FUJIWARA Emi
Kyoto Pharmaceutical University
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松田 久司
Kyoto Pharmaceutical Univ.
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Nakamura Seikou
Department Of Applied Biology Kyoto Institute Of Technology
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MATSUDA HISASHI
Kyoto College of Pharmacy
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