Hepatoprotective and Antioxidative Properties of Salacia reticulata : Preventive Effects of Phenolic Constituents on CCl_4-Induced Liver Injury in Mice
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概要
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The hepatoprotective effects of the hot water(SRHW)and methanolic(SRM)extracts from the roots and stems of Salacia reticulata were examined using an oxidative stress-induced liver injury model. Both SRHW and SRM extracts(400 mg/kg, p.o.)significantly suppressed the increase in glutamic oxaloacetic transaminase(GOT)and glutamic pyruvic transaminase(GPT)activities in carbon tetrachloride(CCl_4)-treated mice. These extracts also inhibited CCl_4-induced thiobarbituric acid-reactive substance(TBA-RS)formation, which indicates increased lipid peroxidation in the liver. A good correlation(γ=0.945, p<0.01)was observed between the amount of phenolic compounds in the extracts and their inhibitions of TBA-RS formation. The IC_<50> values of the extracts on 1, 1-diphenyl-2-picrylhydrazyl(DPPH)radical scavenging were less than 10 μg/ml and the antioxidative activities of six phenolic compounds from the roots of S. reticulata were examined. Mangiferin, (-)-4'-O-methylepigallocatechin, and(-)-epicatechin-(4β→8)-(-)-4'-O-methylepigallocatechin, which a principal phenolic compounds, showed potent scavenging activity on DPPH radicals and their concentrations required for 50% reduction of 40μ_M DPPH radicals were 5.9, 10, and 3.2 μ_M, respectively. On the other hand, against the CCl_4-induced serum GOT and GPT elevations and TBA-RS formation in mice, mangiferin and(-)-4'-O-methylepigallocatechin showed potent activity at a dose of 100 mg/kg, but(-)-epicatechin-(4β→8)-(-)-4'-O-methylepigallocatechin did not. These results suggest that the antioxidative activity of the principal phenolic compounds is involved in the hepatoprotective activity of S. reticulata.
- 社団法人日本薬学会の論文
- 2002-01-01
著者
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MATSUDA Hisashi
Kyoto Pharmaceutical University
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YOSHIKAWA Masayuki
Kyoto Pharmaceutical University
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吉川 雅之
Kyoto Pharmaceutical Univ.
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NINOMIYA Kiyofumi
Kyoto Pharmaceutical University
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Harima S
Kyoto Pharmaceutical Univ. Kyoto Jpn
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SHIMODA Hiroshi
Research and Development Division, Morishita Jintan Co., Ltd.
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NISHIDA Norihisa
Kyoto Pharmaceutical University
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Harima Shoichi
京都薬科大学
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Harima Shoichi
Kyoto Pharmaceutical University:department Of Traditional Chinese Medicine Shenyang Pharmaceutical U
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Shimada Hideyo
Division Of Pathophysiology School Of Pharmaceutical Sciences Kitasato University
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Yamazaki M
School Of Pharmaceutical Sciences Kinki University
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Shimoda Hiroshi
Research & Development Division Oryza Oil & Fat Chemical Co. Ltd.
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Nishida N
Kyoto Pharmaceutical University
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Nishida N
Kyoto Pharmaceutical Univ. Kyoto Jpn
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Nakatani K
Pharmaceutical Res. And Technol. Inst. Kinki Univ.
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MATSUDA HISASHI
Kyoto College of Pharmacy
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