Structures of New Flavonoids, Erycibenins D, E, and F, and NO Production Inhibitors from Erycibe expansa Originating in Thailand

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概要

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• A new flavanol, erycibenin D, and two new flavans, erycibenins E and F, were isolated from the stems of Erycibe expansa originating in Thailand. The structures of new flavonoids were elucidated on the basis of chemical and physicochemical evidence. In addition, the inhibitory activities of the isolated constituents from E. expansaon lipopolysaccharide-activated nitric oxide production in mouse peritoneal macrophages were examined. Among the principal constituents, two isoflavones, clycosin (IC_<50>=13μM) and erythrinin B (18μM), and two rotenoids, deguelin (26μM) and rotenone (27μM), were found to show potent inhibitory activity.

• 公益社団法人日本薬学会の論文
• 2006-11-01

著者

• MATSUDA Hisashi

  Kyoto Pharmaceutical University

• YOSHIKAWA Masayuki

  Kyoto Pharmaceutical University

• Morikawa Toshio

  Kyoto Pharmaceutical University

• 森川 敏生

  Pharmaceutical Res. And Technol. Inst. Kinki Univ.

• 吉川 雅之

  Kyoto Pharmaceutical Univ.

• 山崎 幹夫

  千葉大学薬学部

• Mitani Hidetsugu

  三重大学 第2内科

• Xu Fengming

  Kyoto Pharmaceutical University

• Yamazaki M

  School Of Pharmaceutical Sciences Kinki University

• MATSUDA HISASHI

  Kyoto College of Pharmacy

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