Inhibitors of Nitric Oxide Production from the Flowers of Angelica furcijuga : Structures of Hyuganosides IV and V
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概要
- 論文の詳細を見る
The methanolic extract from the flowers of Angelica furcijuga KITAGAWA was found to inhibit nitric oxide production in lipopolysaccharide-activated mouse peritoneal macrophages. From the methanolic extract, two new glycosides, hyuganosides IV and V, were isolated together with 28 known constituents. The structures of the new constituents were determined on the basis of chemical and physicochemical evidence. Furthermore, the inhibitory effects of 11 coumarin constituents on nitric oxide production were examined. Among them, 3'-an-geloyl-cis-khellactone (IC_<50>=82μM), (S)-(-)-oxypeucedanin (57μM), imperatorin (60μM), isoepoxypteryxin (53μM), and isopteryxin (8.8μM) showed inhibitory activity.
- 公益社団法人日本薬学会の論文
- 2005-04-01
著者
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MATSUDA Hisashi
Kyoto Pharmaceutical University
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YOSHIKAWA Masayuki
Kyoto Pharmaceutical University
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Morikawa Toshio
Kyoto Pharmaceutical University
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吉川 雅之
Kyoto Pharmaceutical Univ.
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Miwa H
Second Department Of Internal Medicine Mie University School Of Medicine
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NISHIDA Norihisa
Kyoto Pharmaceutical University
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Miwa Hiroshi
三重大学 第2内科
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Nishida N
Kyoto Pharmaceutical University
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OHGUSHI Teruki
Kyoto Pharmaceutical University
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ISHIWADA Tomoko
Kyoto Pharmaceutical University
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Ishiwada T
Kyoto Pharmaceutical Univ. Kyoto Jpn
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Nishida N
Kyoto Pharmaceutical Univ. Kyoto Jpn
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MATSUDA HISASHI
Kyoto College of Pharmacy
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