Nigellamines A_3, A_4, A_5, and C, New Dolabellane-Type Diterpene Alkaloids, with Lipid Metabolism-Promoting Activities from the Egyptian Medicinal Food Black Cumin
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概要
- 論文の詳細を見る
New dolabellane-type diterpene alkaloids, nigellamines A_3, A_4, A_5, and C, were isolated from the methanolic extract of an Egyptian medicinal food, black cumin (the seeds of Nigella sativa). Their absolute configurations were determined on the basis of chemical and physicochemical evidence. Nigellamines were found to lower triglyceride levels in primary cultured mouse hepatocytes, and in particular, the activity of nigellamine A_5 was equivalent to that of the hypolipidemic agent, clofibrate.
- 公益社団法人日本薬学会の論文
- 2004-04-01
著者
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MATSUDA Hisashi
Kyoto Pharmaceutical University
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YOSHIKAWA Masayuki
Kyoto Pharmaceutical University
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Morikawa Toshio
Kyoto Pharmaceutical University
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吉川 雅之
Kyoto Pharmaceutical Univ.
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山崎 幹夫
千葉大学薬学部
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NINOMIYA Kiyofumi
Kyoto Pharmaceutical University
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Xu Fengming
Kyoto Pharmaceutical University
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Nakatani K
Pharmaceutical Res. And Technol. Inst. Kinki Univ.
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MATSUDA HISASHI
Kyoto College of Pharmacy
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