Bioactive Saponins and Glycosides. XI. Structures of New Dammarane-Type Triterpene Oligoglycosides, Quinquenosides I, II, III, IV, and V, from American Ginseng, the Roots of Panax quinquefolium L.
スポンサーリンク
概要
- 論文の詳細を見る
The methanolic extract and 1-butanol-soluble fraction of American ginseng, the roots of Panax quinquefolium L., were found to exhibit a protective effect on liver injury induced by D-galactosamine and lipopolysaccharide. Five new dammarane-type triterpene oligoglycosides called quinquenosides I, II, III, IV, and V were isolated together with fourteen known dammarane-type triterpene oligoglycosides such as chikusetsusaponin IVa, pseudo-ginsenoside-RC_1,malonyl-ginsenoside-Rb_1,and notoginsenosides-A, -C, and -K from the 1-butanol-soluble fraction. From the ethyl acetate-soluble fraction, four known acetylenic compounds and 6'-O-acetyl ginsenoside-Rg_1 were isolated. The structures of quinquenosides I, II, III, IV, and V were determined on the basis of chemical and physicochemical evidence as 3-O-[6-O-(E)-2-butenoyl-β-D-glucopyranosyl(1→2)-β-D-glucopyranosyl]-20-O-(β-D-glucopyranosyl) 20(S)-protopanaxadiol (quinquenoside I), 3-O-[6-O-(E)-2-octenoyl-β-D-glucopyranosyl(1→2)-β-D-glucopyranosyl]-20-O-[β-D-glucopyranosyl(1→6)-β-D-glucopyranosyl]20(S)-protopanaxadiol (quinquenoside II), 3-O-[β-D-glucopyranosyl(1→2)-6-O-acetyl-β-D-glucopyranosyl]-20-O-(β-D-glucopyranosyl) 20(S)-protopanaxadiol (quinquenoside III), 3-O-[β-D-glucopyranosyl(1→2)-β-D-glucopyranosyl]-20-O-[β-D-glucopyranosyl(1→6)-β-D-glucopyranosyl]-3β, 7β, 20(S)-trihydroxydammar-5,24-diene (quinoquenoside IV), and 3-O-[β-D-glucopyranosyl(1→2)-β-D-glucopyranosyl]-20-O-[α-D-glucopyranosyl(1→4)-β-D-glucopyranosyl(1→6)-β-D-glucopyranosyl]20(S)-protopanaxadiol (quinquenoside V).
- 社団法人日本薬学会の論文
- 1998-04-15
著者
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MATSUDA Hisashi
Kyoto Pharmaceutical University
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YOSHIKAWA Masayuki
Kyoto Pharmaceutical University
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田中 修
甲南大 理工
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田中 修
甲南大・理工・生物
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山崎 幹夫
千葉大学薬学部
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KATO Yasuyo
Kyoto Pharmaceutical University
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MURAKAMI Toshiyuki
Kyoto Pharmaceutical University
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Tanaka O
Institute Of Pharmaceutical Sciences Faculty Of Medicine Hiroshima University
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鎌田 喜一郎
長岡技術科学大学化学系
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YASHIRO Kenichi
Kyoto Pharmaceutical University
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YAMAHARA Johji
Kyoto Pharmaceutical University
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SAIJOH Reiko
New Product Development Division, Teikoku Seiyaku Co., Ltd.,
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TANAKA Osamu
Suzugamine Women's College
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Saijoh Reiko
New Product Development Division Teikoku Seiyaku Co. Ltd.
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Yamahara J
Kyoto Pharmaceutical University
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Tanaka O
Department Of Biology Faculty Of Science And Engineering Konan University
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Saijoh Reiichi
Unit Of Chemistry Faculty Of Engineering And High Technology Research Center Kansai University
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Tanaka O
Institute Of Pharmaceutical Sciences Hiroshima University School Of Medicine
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YAMAHARA JOHJI
Kyoto College of Pharmacy
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MATSUDA HISASHI
Kyoto College of Pharmacy
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Murakami Toshiyuki
Kyoto Institute of Technology
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