Bioactive Saponins and Glycosides. XXVII. Structures of New Cucurbitane-Type Triterpene Glycosides and Antiallergic Constituents from Citrullus colocynthis
スポンサーリンク
概要
- 論文の詳細を見る
The methanolic extract from the fruit of Citrullus colocynthis showed an inhibitory effect on ear passive cutaneous anaphylaxis reactions as a type I allergic model in mice. From the methanolic extract, two new cucurbitane-type triterpene glycosides, colocynthosides A and B, were isolated together with 17 known constituents. The structures of colocynthosides A and B were elucidated on the basis of chemical and physicochemical evidence. In addition, the principal cucurbitane-type triterpene glycoside, cucurbitacin E 2-O-β-D-glucopyranoside, and its aglycon, cucurbitacin E, exhibited the antiallergic activity at a dose of 100 and 1.25 mg/kg, p.o., respectively.
- 公益社団法人日本薬学会の論文
- 2007-03-01
著者
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NAKAMURA Seikou
Kyoto Pharmaceutical University
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MATSUDA Hisashi
Kyoto Pharmaceutical University
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YOSHIKAWA Masayuki
Kyoto Pharmaceutical University
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Morikawa Toshio
Kyoto Pharmaceutical University
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森川 敏生
Pharmaceutical Res. And Technol. Inst. Kinki Univ.
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吉川 雅之
Kyoto Pharmaceutical Univ.
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山崎 幹夫
千葉大学薬学部
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Hiwatashi Kazuyuki
秋田県農林水産技術センター総合食品研究所
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Hiwatashi Kazuyuki
東北大学 農学研究科栄養学
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松田 秀秋
近畿大学 薬学部
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Miyashita Hiroyuki
三重大学 医学部内科学第2
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Mitani Hidetsugu
三重大学 第2内科
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Hirano Kaoru
Faculty Of Pharmaceutical Sciences Kobe Gakuin University
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Yamazaki M
School Of Pharmaceutical Sciences Kinki University
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前田 初男
大阪大学大学院薬学研究科分子薬科学専攻
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MATSUHIRA Koudai
Kyoto Pharmaceutical University
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Kojima Hiroaki
R & D Company Kobayashi Pharmaceutical Co. Ltd.
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Nakamura Akihiko
Kyoto Pharmaceutical University
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Hori K
Kao Co. Ltd. Tochigi Jpn
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Hori Kazuyuki
The Central Research Laboratory Hitachi Ltd.
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KOBAYASHI Hisanori
Kyoto Pharmaceutical University
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松田 久司
Kyoto Pharmaceutical Univ.
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Kojima Hiroaki
R&d Co. Kobayashi Pharmaceutical Co. Ltd.
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Kojima Hiroaki
Kobayashi Pharmaceutical Co. Ltd. R&d Company
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Nakamura Seikou
Department Of Applied Biology Kyoto Institute Of Technology
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Nakamura Akihiko
Kyoto Pharmaceutical Univ.
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MATSUDA HISASHI
Kyoto College of Pharmacy
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