Antidiabetogenic Constituents from the Thai Traditional Medicine Cotylelobium melanoxylon
スポンサーリンク
概要
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The methanolic extracts from the wood and bark of Cotylelobium melanoxylon were found to inhibit plasma glucose elevation after sucrose loading in rats and triglyceride elevation after olive oil loading in mice. A new stilbene dimer, melanoxylin A, together with the known stilbene dimers [(+)-ampelopsin F, (+)-isoampelopsin F, and (+)-ε-viniferin] and a trimer (vaticanol G) and a lignan [(+)-lyoniresinol] were isolated from the wood extract, and a new stilbene trimer, melanoxylin B, together with the known stilbene dimers [(+)-ε-viniferin and cis-(+)-ε-viniferin] and trimers (vaticanols A, E, and G) were isolated from the bark extract of C. melanoxylon. The principal constituents, vaticanols A, E, and/or G, inhibited plasma glucose and triglyceride elevation after sucrose loading in rats and olive oil loading in mice, respectively. In addition, vaticanols A, E, and/or G inhibited the enzyme activities of rat intestinal α-glucosidase, porcine pancreatic lipase, and rat lens aldose reductase.
著者
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SUGIMOTO Sachiko
Kyoto Pharmaceutical University
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NAKAMURA Seikou
Kyoto Pharmaceutical University
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MATSUDA Hisashi
Kyoto Pharmaceutical University
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YOSHIKAWA Masayuki
Kyoto Pharmaceutical University
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ASAO Yasunobu
Kyoto Pharmaceutical University
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HAMAO Makoto
Kyoto Pharmaceutical University
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前田 初男
大阪大学大学院薬学研究科分子薬科学専攻
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前田 初男
大阪大学大学院薬学研究科
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Maeda Hatsuo
Faculty Of Pharmaceutical Sciences Osaka University
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Asao Y
Kyoto Pharmaceutical University
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Pongpiriyadacha Yutana
Faculty of Science and Technology, Rajamangala University of Technology Srivijaya
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Hongo Masako
Kyoto Pharmaceutical University
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Nakamura Seikou
Department Of Applied Biology Kyoto Institute Of Technology
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Hamao Makoto
Kyoto Pharmaceutical Univ.
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Pongpiriyadacha Yutana
Faculty Of Science And Technology Rajamangala University Of Technology Srivijaya
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MATSUDA HISASHI
Kyoto College of Pharmacy
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