Bioactive Saponins and Glycosides. IX. Notoginseng (2) : Structures of Five New Dammarane-Type Triterpene Oligoglycosides, Notoginsenosides-E, -G, -H, -I, and -J, and a Novel Acetylenic Fatty Acid Glycoside, Notoginsenic Acid β-Sophoroside, from the Dried

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概要

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• Following the characterization of notoginsenosides-A, -B, -C, and -D, new dammarane-type triterpene oligoglycosides, notoginsenosides-E, -G, -H, -I, and -J, and a novel acetylenic fatty acid glycoside, notoginsenic acid β-sophoroside, were isolated from the glycoside fraction with hepatoprotecting activity obtained from the dried roots of Panax notoginseng (BURK.) F. H. CHEN. Their chemical structures were elucidated on the basis of chemical and physicochemical evidence as follows : notoginsenoside E; 3-O-[β-D-glucopyranosyl(1→2)-β-D-glucopyranosyl]-20-O-(β-D-glucopyranosyl)-3β, 12β, 20(S)-trihydroxy-25-hydroperoxydammar-23-ene, G; 3-O-[β-D-glucopyranosyl-(1→2)-β-D-glucopyranosyl]-20-O-(β-D-glucopyranosyl)-3β, 7β, 20(S)-trihydroxydammar-5,24-diene, H; 6-O-[β-D-xylopyranosyl(1→2)-β-D-glucopyranosyl]-20-O-(β-D-glucopyranosyl)-3β, 6α, 12β, 20(S), 25-pentahydroxydammar-23-ene, I; 3-O-[β-D-glucopyranosyl(1→2)-β-D-glucopyranosyl]-20-O-[β-D-glucopyranosyl(1→6)-β-D-glucopyranosyl]-3β, 20(S)-dihydroxydammar-24-ene, J; 6-O-(β-D-glucopyranosyl)-20-O-(β-D-glucopyranosyl)-3β, 6α, 12β, 20(S), 24ζ, 25-hexahydroxydammarane, and notoginsenic acid β-sophoroside; 10-hydroxydaca-4,6-diynoic acid 10-O-β-D-glucopyranosyl (1→2)-β-D-glucopyranoside, respectively.

• 社団法人日本薬学会の論文
• 1997-06-15

著者

• MATSUDA Hisashi

  Kyoto Pharmaceutical University

• YOSHIKAWA Masayuki

  Kyoto Pharmaceutical University

• 田中 修

  甲南大 理工

• 田中 修

  甲南大・理工・生物

• 山崎 幹夫

  千葉大学薬学部

• 村上 啓寿

  阪大院薬

• KATO Yasuyo

  Kyoto Pharmaceutical University

• MURAKAMI Toshiyuki

  Kyoto Pharmaceutical University

• MURAKAMI Nobutoshi

  Kyoto Pharmaceutical University

• 上野 高裕

  Kyoto Pharmaceutical University

• Tanaka O

  Institute Of Pharmaceutical Sciences Faculty Of Medicine Hiroshima University

• 鎌田 喜一郎

  長岡技術科学大学化学系

• YASHIRO Kenichi

  Kyoto Pharmaceutical University

• YAMAHARA Johji

  Kyoto Pharmaceutical University

• SAIJOH Reiko

  New Product Development Division, Teikoku Seiyaku Co., Ltd.,

• TANAKA Osamu

  Suzugamine Women's College

• UENO Takahiro

  Kyoto Pharmaceutical University

• HIROKAWA Nobuko

  Kyoto Pharmaceutical University

• 植田 知彦

  京都薬科大学

• UEMURA Toshiaki

  Kyoto Pharmaceutical University

• 村上 啓寿

  阪大院薬:presto

• Matsumura N

  Res. Foundation Itsuu Lab. Tokyo Jpn

• Saijoh Reiko

  New Product Development Division Teikoku Seiyaku Co. Ltd.

• Yamahara J

  Kyoto Pharmaceutical University

• Uemura Toshiaki

  Department Of Information Electronics Graduate School Of Engineering Nagoya University

• Ueno Takahiro

  Department Of Respiratory Diseases Institute Of Clinical Medicine University Of Tsukuba

• Ueno T

  Kyoto Pharmaceutical University

• Tanaka O

  Department Of Biology Faculty Of Science And Engineering Konan University

• Ueno Takahiro

  Graduate Course Of Mechanical Engineering Mie University

• Saijoh Reiichi

  Unit Of Chemistry Faculty Of Engineering And High Technology Research Center Kansai University

• Tanaka O

  Institute Of Pharmaceutical Sciences Hiroshima University School Of Medicine

• YAMAHARA JOHJI

  Kyoto College of Pharmacy

• MATSUDA HISASHI

  Kyoto College of Pharmacy

• Murakami Toshiyuki

  Kyoto Institute of Technology

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