Medicinal Flowers.III.^<1)> Marigold.(1) : Hypoglycemic, Gastric Emptying Inhibitory, and Gastroprotective Principles and New Oleanane-Type Triterpene Oligoglycosides, Calendasaponins A, B, C and D, from Egyptian Calendula officinalis
スポンサーリンク
概要
- 論文の詳細を見る
The methanolic extract and its 1-butanol-soluble fraction from the floweres of Calendula officinalis were found to show a hypoglycemic effect, inhibitory activity of gastric emptying, and gastroprotective effect. From the 1-butanol-soluble fraction, four new triterpene oligoglycosides, calendasaponins A, B, C, and D, were isolated, together with eight known saponins, seven known flavonol glycosides, and a known sesquiterpene glucoside. Their structures were elucidated on the basis of chemical and physicochemical evidence. The principal saponin constituents, glycosides A, B, C, D, and F, exhibited potent inhibitory effects on an increase in serum glucose levels in glucose-loaded rats, gastric emptying in mice, and ethanol- and indomethacin-induced gastric lesions in rats. Some structure-activity relationsphips are discussed.
- 公益社団法人日本薬学会の論文
- 2001-07-01
著者
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MATSUDA Hisashi
Kyoto Pharmaceutical University
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YOSHIKAWA Masayuki
Kyoto Pharmaceutical University
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村上 敏之
京都薬科大学生薬学教室
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吉川 雅之
Kyoto Pharmaceutical Univ.
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村上 孝之
Taiho Pharmaceutical Co. Ltd.
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MURAKAMI Toshiyuki
Kyoto Pharmaceutical University
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KISHI Akinobu
Kyoto Pharmaceutical University
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KAGEURA Tadashi
Kyoto Pharmaceutical University
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Kishi A
Kyoto Pharmaceutical University
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Murakami Takayuki
Taiho Pharmaceutical Co. Ltd.
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Yamazaki M
School Of Pharmaceutical Sciences Kinki University
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Kageura Tadashi
Department Of Pathological Biochemistry Kyoto Pharmceutical University
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MATSUDA HISASHI
Kyoto College of Pharmacy
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Murakami Toshiyuki
Kyoto Institute of Technology
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