Antidiabetogenic constituents from Salacia species(Chemical & Pharmacological study)
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概要
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In the course of our studies on antidiabetogenic compounds from natural medicines and medicinal foodstuffs, we found that the extracts from the roots and stems of Salacia reticulata, S. oblonga, and S. chinensis showed substantial inhibitory effects on increase in serum glucose levels in oral sucrose- and maltose-loaded rats and inhibitory effects on intestinal α-glucosidase. Through bioassay-guided separation using α-glucosidase inhibitory activities, we isolated α-glucosidase inhibitors named salacinol and kotalanol with unique chemical structures from the active fractions together with several known phenolic compounds, new sesquiterpenes (salasols A and B) and triterpenes (kotalagenin 16-acetate, salasones A-E, salaquinones A and B). Furthermore, S. reticulata and its phenolic constituents were found to exhibit pancreatic lipase inhibitory and anti-obese effects. This paper summarizes our recent studies including the synthetic and structure-activity relationships on antidiabetogenic principles of Salacia species. In addition, clinical studies and safety evaluations of the extracts from S. reticulata and S. oblonga are summarized.
- 和漢医薬学会の論文
著者
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MATSUDA Hisashi
Kyoto Pharmaceutical University
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YOSHIKAWA Masayuki
Kyoto Pharmaceutical University
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吉川 雅之
Kyoto Pharmaceutical Univ.
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Muraoka Osamu
Pharmaceutical Research and Technology Institute, Kinki University
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山崎 幹夫
千葉大学薬学部
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Muraoka Osamu
Pharmaceutical Research And Technology Institute Kinki University
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Muraoka Osamu
近畿大学薬学総合研究所
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Muraoka Osamu
School of Pharmacy, Kinki University
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Tanabe Genzoh
School of Pharmacy, Kinki University
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MORIKAWA Toshio
School of Pharmaceutical Sciences, Kinki University
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Tanabe Genzoh
近畿大学 薬
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Tanabe Genzoh
School Of Pharmaceutical Sciences Kinki University
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Muraoka Osamu
School Of Pharmaceutical Sciences Kinki University
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Yamazaki M
School Of Pharmaceutical Sciences Kinki University
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Tanabe Genzoh
School Of Pharmacy Kinki Univ.
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MATSUDA HISASHI
Kyoto College of Pharmacy
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