Bioactive Saponins and Glycosides. XXIII. : Triterpene Saponins with Gastroprotective Effect from the Seeds of Camellia sinensis : Theasaponins E_3, E_4, E_5, E_6, and E_7
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概要
- 論文の詳細を見る
The saponin fraction from the seeds of the tea plant [Camellia sinensis (L.) O. KUNTZE (Theaceae)] was found to exhibit potent protective effects on ethanol- and indomethacin-induced gastric mucosal lesions in rats. Five new triterpene saponins, theasaponins E_3 (1), E_4 (2), E_5 (3), E_6 (4), and E_7 (5), were isolated together with 11 known saponins from the saponin fraction. The chemical structures of 1-5 were elucidated on the basis of chemical and physicochemical evidence. Among the isolated saponins, theasaponins E_1 (6), E_2 (7), and E_5 (3) and assamsaponin C (10) showed an inhibitory effect on ethanol-induced gastric mucosal lesions at a dose of 5.0mg/kg, p.o. and their activities were stronger than that of omeplazole. With regard to the structure-activity relationships of theasaponins, the following structural requirements for a protective effect on ethanol-induced gastric lesions were suggested; 1) the 21-and/or 22-acyl groups are essential for the activity, 2) acetylation of the 16-hydroxyl group reduce the activity.
- 公益社団法人日本薬学会の論文
- 2005-12-01
著者
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MATSUDA Hisashi
Kyoto Pharmaceutical University
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YOSHIKAWA Masayuki
Kyoto Pharmaceutical University
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Morikawa Toshio
Kyoto Pharmaceutical University
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吉川 雅之
Kyoto Pharmaceutical Univ.
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LI Xuezheng
Kyoto Pharmaceutical University
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山崎 幹夫
千葉大学薬学部
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Mitani Hidetsugu
三重大学 第2内科
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Li Ning
Kyoto Pharmaceutical University:research Department Of Natural Medicine Shenyang Pharmaceutical Univ
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Li Ning
京都薬科大学
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Yamazaki M
School Of Pharmaceutical Sciences Kinki University
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Li Ning
Department Of Chemistry Fudan University
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LI Xian
Research Department of Natural Medicine, Shenyang Pharmaceutical University
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Li Xian
Research Department Of Natural Medicine Shenyang Pharmaceutical University
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Nagatomo Akifumi
Kyoto Pharmaceutical University
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Li N
Kyoto Pharmaceutical University:research Department Of Natural Medicine Shenyang Pharmaceutical Univ
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Li Xuezheng
Kyoto Pharmaceutical Univ.
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Nakamura Akihiko
Kyoto Pharmaceutical Univ.
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MATSUDA HISASHI
Kyoto College of Pharmacy
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