INHIBITORY MECHANISMS OF OLEANOLIC ACID 3-O-MONODESMOSIDES ON GLUCOSE ABSORPTION IN RATS
スポンサーリンク
概要
- 論文の詳細を見る
We examined the action mechanism of oleanolic acid 3-O-monodesmoside, momordin Ic (1), and oleanolic acid 3-O-glucuronide (2) for the inhibitory effect on the increase in serum glucose levels in oral glucose-loaded rats. Although 1 and 2 dose-dependently inhibited the increase in serum glucose levels in oral glucose-loaded rats, these compounds showed no significant effects on serum glucose levels in normal rats, intraperitoneal glucose-loaded rats, and alloxane-induced diabetic mice. Furthermore, 1 and 2 were found to suppress gastric emptying in rats, and also to inhibit the glucose uptake in rat small intestine concentration dependently in vitro. These results indicate that 1 and 2 given orally have neither insulin-like activity nor insulin releasing-activity. 1 and 2 apparently inhibited glucose absorption by suppressing the transfer of glucose from the stomach to the small intestine and by inhibiting the glucose transport system at the small intestinal brush border.
- 社団法人日本薬学会の論文
- 1997-06-15
著者
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MATSUDA Hisashi
Kyoto Pharmaceutical University
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YOSHIKAWA Masayuki
Kyoto Pharmaceutical University
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村上 啓寿
阪大院薬
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MURAKAMI Toshiyuki
Kyoto Pharmaceutical University
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YAMAHARA Johji
Research Institute for Production Development
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MURAKAMI Nobutoshi
Kyoto Pharmaceutical University
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SHIMADA Hiromi
Kyoto Pharmaceutical University
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MATSUMURA Narumi
Kyoto Pharmaceutical University
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Harima S
Kyoto Pharmaceutical Univ. Kyoto Jpn
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村上 啓寿
阪大院薬:presto
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Harima Shoichi
京都薬科大学
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Harima Shoichi
Kyoto Pharmaceutical University:department Of Traditional Chinese Medicine Shenyang Pharmaceutical U
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Matsumura N
Res. Foundation Itsuu Lab. Tokyo Jpn
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Yamahara J
Kyoto Pharmaceutical University
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YAMAHARA JOHJI
Kyoto College of Pharmacy
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MATSUDA HISASHI
Kyoto College of Pharmacy
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Murakami Toshiyuki
Kyoto Institute of Technology
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