Bioactive Constituents from Chinese Natural Medicines. XXVI : Chemical Structures and Hepatoprotective Effects of Constituents from Roots of Rhodiola sachalinensis
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概要
- 論文の詳細を見る
The methanolic extract from the roots of Rhodiola sachalinensis was found to show a protective effect on D-galactosamine-induced cytotoxicity in primary cultured mouse hepatocytes. From the methanolic extract, five new glycosides, two monoterpene glycosides, two flavonol bisdesmosides, and a cyanogenic glycoside, were isolated together with 34 known compounds. The structures of new constituents were elucidated on the basis of chemical and physicochemical evidence. In addition, the principal constituents, sachalosides III and IV, rhodiosin, and trans-caffeic acid, displayed hepatoprotective effects.
- 社団法人日本薬学会の論文
- 2007-10-01
著者
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NAKAMURA Seikou
Kyoto Pharmaceutical University
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MATSUDA Hisashi
Kyoto Pharmaceutical University
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YOSHIKAWA Masayuki
Kyoto Pharmaceutical University
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森川 敏生
Pharmaceutical Res. And Technol. Inst. Kinki Univ.
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吉川 雅之
Kyoto Pharmaceutical Univ.
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Morikawa Toshio
Pharmaceutical Research and Technology Institute, Kinki University
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Ninomiya Kiyofumi
Pharmaceutical Research and Technology Institute, Kinki University
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LI Xuezheng
Kyoto Pharmaceutical University
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YAMAGUTI Kikuji
Japan Royal Jelly Co., Ltd.
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山崎 幹夫
千葉大学薬学部
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松田 秀秋
近畿大学 薬学部
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Miyashita Hiroyuki
三重大学 医学部内科学第2
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Mitani Hidetsugu
三重大学 第2内科
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山田 美紀子
Faculty Of Pharmaceutical Sciences Chiba University
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Yamazaki M
School Of Pharmaceutical Sciences Kinki University
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前田 初男
大阪大学大学院薬学研究科分子薬科学専攻
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前田 初男
大阪大学大学院薬学研究科
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Maeda Hatsuo
Faculty Of Pharmaceutical Sciences Osaka University
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Morikawa Toshio
Pharmaceutical Research And Technology Institute Kinki University
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Morikawa T
Research Institute Fuji Chemical Industries Ltd.
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松田 久司
Kyoto Pharmaceutical Univ.
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Li Xuezheng
Kyoto Pharmaceutical Univ.
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Yamaguti Kikuji
Japan Royal Jelly Co. Ltd.
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Nakamura Seikou
Department Of Applied Biology Kyoto Institute Of Technology
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Nakatani K
Pharmaceutical Res. And Technol. Inst. Kinki Univ.
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MATSUDA HISASHI
Kyoto College of Pharmacy
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