Bioactive Constituents from Chinese Natural Medicines. XXIII. Absolute Structures of New Megastigmane Glycosides, Sedumosides A_4, A_5, A_6, H, and I, and Hepatoprotective Megastigmanes from Sedum sarmentosum
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概要
- 論文の詳細を見る
The methanol-eluted fraction of the hot water extract from the whole plant of Sedum sarmentosum (Crassu-laceae) was found to show hepatoprotective effect on D-galactosamine-induced cytotoxicity in primary cultured mouse hepatocytes. From the active fraction, five new megastigmane glycosides, sedumosides A_4, A_5, A_6, H, and I, were isolated together with 22 megastigmane constituents. Their absolute stereostructures were elucidated on the basis of chemical and physicochemical evidence. Among them, sedumoside F_1 (IC_<50>=47μM), (3S,5R,0S,9R)-megastigmane-3,9-diol (61μM), and myrsinionosides A (52μM) and D (62μM) were found to show the strong hepatoprotective activity.
- 社団法人日本薬学会の論文
- 2007-08-01
著者
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NAKAMURA Seikou
Kyoto Pharmaceutical University
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MATSUDA Hisashi
Kyoto Pharmaceutical University
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YOSHIKAWA Masayuki
Kyoto Pharmaceutical University
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Morikawa Toshio
Kyoto Pharmaceutical University
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森川 敏生
Pharmaceutical Res. And Technol. Inst. Kinki Univ.
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吉川 雅之
Kyoto Pharmaceutical Univ.
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Muraoka Osamu
Pharmaceutical Research and Technology Institute, Kinki University
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山崎 幹夫
千葉大学薬学部
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松田 秀秋
近畿大学 薬学部
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Miyashita Hiroyuki
三重大学 医学部内科学第2
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Muraoka Osamu
Pharmaceutical Research And Technology Institute Kinki University
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Muraoka Osamu
近畿大学薬学総合研究所
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Mitani Hidetsugu
三重大学 第2内科
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NINOMIYA Kiyofumi
Kyoto Pharmaceutical University
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ZHANG Yi
Kyoto Pharmaceutical University
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Yamazaki M
School Of Pharmaceutical Sciences Kinki University
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前田 初男
大阪大学大学院薬学研究科分子薬科学専攻
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Muraoka Osamu
Pharmaceutical Res. And Technol. Inst. Kinki Univ.
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Morikawa T
Research Institute Fuji Chemical Industries Ltd.
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松田 久司
Kyoto Pharmaceutical Univ.
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Nakamura Seikou
Department Of Applied Biology Kyoto Institute Of Technology
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Nakatani K
Pharmaceutical Res. And Technol. Inst. Kinki Univ.
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Zhang Yi
State Key Lab. Of Bioactive Substances And Functions Of Natural Medicines Inst. Of Materia Medica Ch
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MATSUDA HISASHI
Kyoto College of Pharmacy
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