Inhibitory Effects of Thunberginols A, B, and F on Degranulations and Releases of TNF-α and IL-4 in RBL-2H3 Cells(Pharmacognosy)
スポンサーリンク
概要
- 論文の詳細を見る
Thunberginols A, B, and F from the processed leaves of Hydrangea macrophylla van thunbergii (Hydrangeae Dulcis Folium) substantially inhibited the degranulations by antigen and calcium ionophore A23187, and the releases of TNF-α and IL-4 by antigen in RBL-2H3 cells. Phyllodulcin and hydrangenol also showed significant inhibition for the antigen-induced degranulations, but their effects were weaker than those of thunberginols A, B, and F. Among them, thunberginol B showed the most potent activity. With regard to structural requirements of thunberginols for the activity, the 3,4-double bond was essential for the strong activity and the 6-hydroxyl group and lactone ring enhanced the activity. Thunberginols A, B, and F inhibited increase in intracellular free Ca^<2+> levels, which is an essential process for the degranulation and production of cytokines, in RBL-2H3 cells induced by antigen, but not by calcium ionophore A23187. These results suggested that these active compounds inhibited the degranulation processes both before and after increase in intracellular free Ca^<2+> levels.
- 社団法人日本薬学会の論文
- 2007-02-01
著者
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NAKAMURA Seikou
Kyoto Pharmaceutical University
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MATSUDA Hisashi
Kyoto Pharmaceutical University
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YOSHIKAWA Masayuki
Kyoto Pharmaceutical University
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吉川 雅之
Kyoto Pharmaceutical Univ.
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山崎 幹夫
千葉大学薬学部
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松田 秀秋
近畿大学 薬学部
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Miyashita Hiroyuki
三重大学 医学部内科学第2
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Mitani Hidetsugu
三重大学 第2内科
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Wang Qilong
Kyoto Pharmaceutical University
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Dai Yue
School Of Traditional Chinese Medicine Shenyang Pharmaceutical Univ.
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Yamazaki M
School Of Pharmaceutical Sciences Kinki University
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前田 初男
大阪大学大学院薬学研究科分子薬科学専攻
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MATSUHIRA Koudai
Kyoto Pharmaceutical University
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YUAN Dan
Shenyang Pharmaceutical University
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Yuan D
Department Of Traditional Chinese Medicine Shenyang Pharmaceutical University
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Yuan Dan
Department Of Traditional Medicinal Science Hokkaido College Of Pharmacy
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WANG Qilong
Department of Pharmacognosy, 21st Century COE Program, Kyoto Pharmaceutical University
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Yuan D
Shenyang Pharmaceutical Univ. Shenyang Chn
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Wang Qilong
Department Of Pharmacognosy 21st Century Coe Program Kyoto Pharmaceutical University
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Yamazaki Masaharu
Department Of Internal Medicine Nara Medical University
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松田 久司
Kyoto Pharmaceutical Univ.
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Nakamura Seikou
Department Of Applied Biology Kyoto Institute Of Technology
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Yuan Dan
Department Of Traditional Chinese Medicines Shenyang Pharmaceutical University
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MATSUDA HISASHI
Kyoto College of Pharmacy
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