Invasion Inhibitors of Human Fibrosarcoma HT 1080 Cells from the Rhizomes of Zingiber cassumunar: Structures of Phenylbutanoids, Cassumunols
スポンサーリンク
概要
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The methanolic extract and its EtOAc-soluble fraction from the rhizomes of Zingiber cassumunar inhibited invasion of human fibrosarcoma HT 1080 cells. From the EtOAc-soluble fraction, eight new phenylbutanoids, cassumunols A—H, were isolated together with 30 known constituents. The structures of new phenylbutanoids were elucidated on the basis of chemical and physicochemical evidence. Principal constituents were examined the inhibitory effects on the invasion of HT 1080 cells. Among them, phlain I and III, (E)-1-(3,4-dimethoxyphenyl)buta-1,3-diene, (E)-1-(2,4,5-trimethoxyphenyl)buta-1,3-diene, and (−)-β-sesquiphellandrene showed anti-invasion effects. Interestingly, (E)-1-(2,4,5-trimethoxyphenyl)buta-1,3-diene [inhibition (%) 46.8±7.2 (p<0.05) at 30 μM] significantly inhibited the invasion, and only a weak cytotoxic effect was observed.
著者
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NAKAMURA Seikou
Kyoto Pharmaceutical University
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MATSUDA Hisashi
Kyoto Pharmaceutical University
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YOSHIKAWA Masayuki
Kyoto Pharmaceutical University
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LI Xuezheng
Kyoto Pharmaceutical University
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FUKUYAMA Yoshiyasu
Faculty of Pharmaceutical Sciences, Tokushima Bunri University
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Matsuda Hideaki
Laboratory Of Natural Drug Resources Faculty Of Pharmacy Kinki University
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前田 初男
大阪大学大学院薬学研究科分子薬科学専攻
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前田 初男
大阪大学大学院薬学研究科
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Maeda H
Faculty Of Pharmaceutical Sciences Osaka University
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Maeda Hatsuo
Faculty Of Pharmaceutical Sciences Osaka University
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KUBO Miwa
Faculty of Pharmaceutical Sciences, Tokushima Bunri University
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Fukuyama Yoshiyasu
Faculty Of Pharmaceutical Science Tokushima Bunri University
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Kubo Miwa
Faculty Of Pharmaceutical Sciences Tokushima Bunri University
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Li Xuezheng
Kyoto Pharmaceutical Univ.
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Iwami Junko
Kyoto Pharmaceutical University
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Pongpiriyadacha Yutana
Faculty of Science and Technology, Rajamangala University of Technology Srivijaya
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Nakai Megumi
Faculty of Pharmaceutical Sciences, Tokushima Bunri University
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Nakamura Seikou
Department Of Applied Biology Kyoto Institute Of Technology
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Pongpiriyadacha Yutana
Faculty Of Science And Technology Rajamangala University Of Technology Srivijaya
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Nakai Megumi
Faculty Of Chemical And Biological Engineering Hachinohe National College Of Technology
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MATSUDA HISASHI
Kyoto College of Pharmacy
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