Brazilian Natural Medicines. IV. New Noroleanane-Type Triterpene and Ecdysterone-Type Sterol Glycosides and Melanogenesis Inhibitors from the Roots of Pfaffia glomerata
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概要
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The ethyl acetate and 1-butanol soluble fractions of the roots of Pfaffia glomerata were found to show inhibitory effects on melanogenesis in theophylline-stimulated B16 melanoma 4A5 cells. From the ethyl acetate and 1-butanol soluble fractions, we isolated a new noroleanane-type triterpene, pfaffianol A, its glycosides, pfaffiaglycosides A and B, and ecdysterone-type sterol glycosides, pfaffiaglycosides C, D, and E, together with eight known constituents. The structures of new constituents were determined on the basis of physicochemical and chemical evidence. Among them, pfaffianol A (IC50=44 μM) and pfaffoside C (IC50=92 μM) substantially inhibited melanogenesis without cytotoxic effects. The inhibitory effects were stronger than that of reference compound, arbutin (IC50=174 μM).
- 公益社団法人 日本薬学会の論文
著者
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NAKAMURA Seikou
Kyoto Pharmaceutical University
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MATSUDA Hisashi
Kyoto Pharmaceutical University
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YOSHIKAWA Masayuki
Kyoto Pharmaceutical University
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Nakashima Souichi
Kyoto Pharmaceutical University
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Pei Yuehu
School Of Traditional Chinese Materia Medica Shenyang Pharmaceutical Univ.
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Chen Gang
Kyoto Pharmaceutical University
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Nakamura Seikou
Department Of Applied Biology Kyoto Institute Of Technology
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MATSUDA HISASHI
Kyoto College of Pharmacy
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