Medicinal Foodstuffs. VII. On the Saponin Constituents with Glucose and Alcohol Absorption-Inhibitory Activity from a Food Garnish "Tonburi", the Fruit of Japanese Kochia scoparia (L.) SCHRAD. : Structures of Scoparianosides A, B, and C
スポンサーリンク
概要
- 論文の詳細を見る
The methanolic extract of a food garnish "Tonburi", the fruit of Japanese Kochia scoparia (L.) SCHRAD. (Chenopodiaceae), was found to inhibit the increase in serum glucose in glucose-loaded rats. Through bioassay-guided separation, momordin Ic and its 2'-O-β-D-glucopyranoside were isolated as the active principles from this medicinal foodstuff together with three new saponins named scoparianosides A, B, and C. The structures of scoparianosides A, B, and C were elucidated on the basis of chemical and pysicohemical evidence as 3β, 22α-dihydroxyolean-12-en-28-oic acid (22α-hydroxyoleanolic acid), 3-O-β-D-xylopyranoxyl (1→3)-β-D-glucopyranosiduronic acid, 3β-hydroxyolean-18-en-28-oic acid (morolic acid), 3-O-β-D-xylopyranosy(1→3)-β-D-glucopyranosiduronic acid, and 3β-hydroxyolean-13(8)-en-28-oic acid, 3-O-β-D-xylopyranosyl(1→3)-β-D-glucopyranosiduronic acid.Momordin Ic and its 2'-O-β-D-glucopyranoside, both of which are the principal saponin constituents of this medicinal foodstuff, were found to potently inhibit glucose and ethanol absorption in rats.
- 1997-08-15
著者
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MATSUDA Hisashi
Kyoto Pharmaceutical University
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YOSHIKAWA Masayuki
Kyoto Pharmaceutical University
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Morikawa Toshio
Kyoto Pharmaceutical University
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山崎 幹夫
千葉大学薬学部
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Hiwatashi Kazuyuki
秋田県農林水産技術センター総合食品研究所
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村上 啓寿
阪大院薬
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MURAKAMI Toshiyuki
Kyoto Pharmaceutical University
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YAMAHARA Johji
Research Institute for Production Development
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MURAKAMI Nobutoshi
Kyoto Pharmaceutical University
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SHIMADA Hiromi
Kyoto Pharmaceutical University
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MATSUMURA Narumi
Kyoto Pharmaceutical University
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Harima S
Kyoto Pharmaceutical Univ. Kyoto Jpn
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YOSHIZUMI Satoshi
Kyoto Pharmaceutical University
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HORI Kazuyuki
Akita Research Institute of Food and Brewing
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村上 啓寿
阪大院薬:presto
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Harima Shoichi
京都薬科大学
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Harima Shoichi
Kyoto Pharmaceutical University:department Of Traditional Chinese Medicine Shenyang Pharmaceutical U
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Matsumura N
Res. Foundation Itsuu Lab. Tokyo Jpn
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Yoshizumi S
Research And Development Headquaters Hokuriku Seivaku Co. Ltd.
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Yasuda S
Kanazawa Univ. Kanazawa Jpn
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Yasuda Shingo
Research And Development Division Hokuriku Seiyaku Co. Ltd.
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Yamahara J
Kyoto Pharmaceutical University
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Hori K
Kao Co. Ltd. Tochigi Jpn
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Hori Kazuyuki
Akita Research Institute Of Food & Brewing (arif)
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Hori Kazuyuki
The Central Research Laboratory Hitachi Ltd.
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Kojima Hiroaki
R&d Co. Kobayashi Pharmaceutical Co. Ltd.
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Hata K
Akita Research Institute Of Food And Brewing
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Kojima Hiroaki
Kobayashi Pharmaceutical Co. Ltd. R&d Company
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YAMAHARA JOHJI
Kyoto College of Pharmacy
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MATSUDA HISASHI
Kyoto College of Pharmacy
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Murakami Toshiyuki
Kyoto Institute of Technology
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Hori Kazuyuki
Akita Research Institute for Food and Brewing
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