Studies on Kochiae Fructus. V. Antipruritic Effects of Oleanolic Acid Glycosides and the Structure-Requirement
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概要
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We examined the antipruritic effects of various oleanolic acid glycosides from natural medicines such as Kochiae Fructus (the fruit of Kochia scoparia SCHRAD.) and Momordicae Radix (the roots of Momordica cochinchinensis SPRENG.) using a compound 48/80-induced pruritic model in mice. Oleanolic acid 3-O-monodesmosides showed an antipruritic effect, while oleanolic acid 3,28-O-bisdesmosides and their common sapogenol oleanolic acid lacked the activity. This evidence indicated that the 3-O-glycoside moiety and the 28-carboxyl group in oleanolic acid glycosides were essential for exhibiting the antipruritic effect. Furthermore, it was found that the 3-O-glucuronides showed more potent activity than the corresponding 3-O-glucosides.
- 1998-11-15
著者
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MATSUDA Hisashi
Kyoto Pharmaceutical University
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YOSHIKAWA Masayuki
Kyoto Pharmaceutical University
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村上 孝之
Taiho Pharmaceutical Co. Ltd.
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MURAKAMI Toshiyuki
Kyoto Pharmaceutical University
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角谷 真
京都薬科大学
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Matsuda Hideaki
Faculty of Pharmacy, Kinki University
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Kubo M
School Of Pharmaceutical Sciences Kinki University
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Kubo Michinori
近畿大学 薬学部
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KUBO Michinori
Faculty of Pharmaceutical Sciences, Kinki University
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IDO Yasuko
Faculty of Pharmaceutical Sciences, Kinki University
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DAI Yue
China Pharmaceutical University
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Dai Yue
School Of Traditional Chinese Medicine Shenyang Pharmaceutical Univ.
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Kubo Michinori
Faculty Of Pharmaceutical Sciences Kinki University
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Matsuda Hideaki
Faculty Of Pharmaceutical Sciences Kinki University
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Yuan D
Department Of Traditional Chinese Medicine Shenyang Pharmaceutical University
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Yuan Dan
Department Of Traditional Medicinal Science Hokkaido College Of Pharmacy
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Dai Y
School Of Traditional Chinese Medicine Shenyang Pharmaceutical Univ.
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Yuan D
Shenyang Pharmaceutical Univ. Shenyang Chn
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Kubo M
Faculty Of Pharmaceutical Sciences Tokushima Bunri University
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Ido Yasuko
Faculty Of Pharmaceutical Sciences Kinki University
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Yuan Dan
Department Of Traditional Chinese Medicines Shenyang Pharmaceutical University
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MATSUDA HISASHI
Kyoto College of Pharmacy
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Murakami Toshiyuki
Kyoto Institute of Technology
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