Medicinal Flowers. XXIV. Chemical Structures and Hepatoprotective Effects of Constituents from Flowers of Hedychium coronarium
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概要
- 論文の詳細を見る
The 80% aqueous acetone extract from the flowers of Hedychium coronarium was found to show a protective effect on D-galactosamine-induced cytotoxicity in primary cultured mouse hepatocytes. On the other hand, two new labdane-type diterpene glycosides, coronalactosides I (1) and II (2), and a new labdane-type trinorditerpene, coronadiene (3), were isolated together with 8 known compounds from the extracts, which were obtained with chloroform and 80% aqueous acetone from the flowers of H. coronarium. The structures of new constituents were elucidated on the basis of chemical and physicochemical evidence. In addition, the principal constituents, coronaririn C and 15-hydroxylabda-8(17),11,13-trien-16,15-olide, displayed hepatoprotective effects, which were stronger than that of the hepatoprotective agent, silybin.
- 社団法人日本薬学会の論文
- 2008-12-01
著者
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NAKAMURA Seikou
Kyoto Pharmaceutical University
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MATSUDA Hisashi
Kyoto Pharmaceutical University
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YOSHIKAWA Masayuki
Kyoto Pharmaceutical University
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森川 敏生
Pharmaceutical Res. And Technol. Inst. Kinki Univ.
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吉川 雅之
Kyoto Pharmaceutical Univ.
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Morikawa Toshio
Pharmaceutical Research and Technology Institute, Kinki University
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Ninomiya Kiyofumi
Pharmaceutical Research and Technology Institute, Kinki University
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OKAZAKI Yoshie
Kyoto Pharmaceutical University
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山崎 幹夫
千葉大学薬学部
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松田 秀秋
近畿大学 薬学部
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山崎 幹夫
千葉大学薬学部医薬品素材学講座
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Miwa H
Second Department Of Internal Medicine Mie University School Of Medicine
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Miyashita Hiroyuki
三重大学 医学部内科学第2
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Mitani H
Second Department Of Internal Medicine Mie University School Of Medicine
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Mitani Hidetsugu
Division Of Hematology And Oncology Suzuka General Hospital
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Mitani Hidetsugu
三重大学 第2内科
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Miwa Hiroshi
三重大学 第2内科
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Yamazaki Masatoshi
Faculty Of Pharmaceutical Sciences Teikyo University Sagamiko
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山田 美紀子
Faculty Of Pharmaceutical Sciences Chiba University
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Matsuda Hajime
Nihon Shokuhin Kako Co. Ltd.
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Yamazaki M
School Of Pharmaceutical Sciences Kinki University
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Matsuda Hideaki
Laboratory Of Natural Drug Resources Faculty Of Pharmacy Kinki University
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前田 初男
大阪大学大学院薬学研究科分子薬科学専攻
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前田 初男
大阪大学大学院薬学研究科
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Maeda Hatsuo
Faculty Of Pharmaceutical Sciences Osaka University
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Morikawa Toshio
Pharmaceutical Research And Technology Institute Kinki University
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Morikawa T
Research Institute Fuji Chemical Industries Ltd.
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Maeda Haruka
The Institute Of Physical And Chemical Research(riken)
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松田 久司
Kyoto Pharmaceutical Univ.
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Nakamura Seikou
Department Of Applied Biology Kyoto Institute Of Technology
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Nakatani K
Pharmaceutical Res. And Technol. Inst. Kinki Univ.
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Nakamura Seikou
Department of Applied Biology, Kyoto Institute of Technology
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MATSUDA HISASHI
Kyoto College of Pharmacy
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