Chemical Structures and Hepatoprotective Effects of Constituents from the Leaves of Salacia chinensis
スポンサーリンク
概要
- 論文の詳細を見る
The methanolic extract from the leaves of Salacia chinensis collected in Thailand was found to show a protective effect on D-galactosamine-induced cytotoxicity in primary cultured mouse hepatocytes. From the methanolic extract, eight new glycosides, named foliachinenosides E, F, G, H, and I, and foliasalaciosides J, K and L, were isolated together with 26 known constituents. The structures of new glycosides were determined on the basis of physicochemical and chemical evidence. In addition, the hepatoprotective effects of the isolated compounds on D-galactosamine-induced cytotoxicity were examined. Among them, lignans, eleutheroside E2 and 7R,8S-dihydrodehydrodiconiferyl alcohol 4-O-β-D-glucopyranoside, were found to show the protective effects [inhibition (%) 41.4±3.6 (p<0.01), 45.5±2.7 (p<0.01) at 100 μM, respectively].
- 公益社団法人 日本薬学会の論文
著者
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NAKAMURA Seikou
Kyoto Pharmaceutical University
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MATSUDA Hisashi
Kyoto Pharmaceutical University
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YOSHIKAWA Masayuki
Kyoto Pharmaceutical University
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Ninomiya Kiyofumi
Pharmaceutical Research and Technology Institute, Kinki University
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ZHANG Yi
Kyoto Pharmaceutical University
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Matsuda Hideaki
Laboratory Of Natural Drug Resources Faculty Of Pharmacy Kinki University
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前田 初男
大阪大学大学院薬学研究科分子薬科学専攻
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前田 初男
大阪大学大学院薬学研究科
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Maeda H
Faculty Of Pharmaceutical Sciences Osaka University
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Maeda Hatsuo
Faculty Of Pharmaceutical Sciences Osaka University
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Muraoka Osamu
Pharmaceutical Res. And Technol. Inst. Kinki Univ.
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Nakamura Seikou
Department Of Applied Biology Kyoto Institute Of Technology
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MATSUDA HISASHI
Kyoto College of Pharmacy
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