The Synthesis of Isoquinoline Alkaloid and Its Related Compounds Using Alanine Derivatives as Chiral Auxiliaries

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概要

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• Chiral 1-substituted isoquinoline derivatives, which were obtained by the reaction using alanine derivatives as chiral auxiliaries, were transformed to (S)-2,3,9,10,11-pentamethoxyhomoprotoberberine (7) and a synthetic intermediate for O-methylkreysigine (9) in good yields and high stereoselectivity. The corresponding chiral allyl derivative of isoquinoline was transformed to a pyrrolidinoisoquinoline (16) in a highly enantioselective manner.

• 公益社団法人日本薬学会の論文
• 2003-08-01

著者

• NAKAMURA Seikou

  Kyoto Pharmaceutical University

• 中村 紳一郎

  Specialty Chemicals Research Center Shin-etsu Chemical Co. Ltd.

• 伊藤 喬

  昭和大学薬学部

• 伊藤 喬

  昭和大学薬学部薬化学教室

• Yamazaki Mami

  Department Of Molecular Biology And Biotechnology Graduate School Of Pharmaceutical Sciences Chiba U

• Itoh T

  Graduate School Of Pharmaceutical Sciences Osaka University

• Itoh Takuya

  Graduate School Of Pharmaceutical Sciences Osaka University

• Itoh Tatsuya

  Faculty Of Pharmaceutical Sciences Hokuriku University

• Yokota M

  School Of Pharmaceutical Sciences Showa University

• Nakamura S

  Toyama Univ. Toyama Jpn

• Nagata K

  School Of Pharmaceutical Sciences Showa University

• Nakamura S

  Specialty Chemicals Research Center Shin-etsu Chemical Co. Ltd.

• Miyazaki Michiko

  School of Pharmaceutical Sciences, Showa University

• Nagata Kazuhiro

  School of Pharmaceutical Sciences, Showa University

• Itoh Takashi

  School of Pharmaceutical Sciences, Showa University

• Yokota Masashi

  School of Pharmaceutical Sciences, Showa University

• Kameoka Keiko

  School of Pharmaceutical Sciences, Showa University

• Nakamura Shigeru

  School of Pharmaceutical Sciences, Showa University

• Ohsawa Akio

  School of Pharmaceutical Sciences, Showa University

• Nakamura Satoko

  Osaka University Of Pharmaceutical Sciences

• Miyazaki Makoto

  Department Of Pharmaceutics Osaka University Of Pharmaceutical Sciences

• Narimatsu Shizuo

  Laboratories Of Health Chemistry Graduate School Of Medicine Dentistry And Pharmaceutical Sciences O

• Ohsawa A

  School Of Pharmaceutical Sciences Showa University

• Ohsawa Akio

  School Of Pharmaceutical Sciences Showa University

• Kameoka Keiko

  School Of Pharmaceutical Sciences Showa University

• Yokoya M

  Chiba Univ. Chiba Jpn

• Narimatsu Shizuo

  Department Of Hygienic Chemistry Faculty Of Pharmaceutical Sciences Hokuriku University

• Nakamura S

  Laboratories Of Health Chemistry Graduate School Of Medicine Dentistry And Pharmaceutical Sciences O

• 永田 和弘

  School Of Pharmaceutical Sciences Showa University

• Nagata Kazuhiro

  School Of Pharmaceutical Sciences Showa University

• Itoh Takashi

  School Of Pharmaceutical Sciences Showa University

• Yokoya Masashi

  School of Pharmaceutical Sciences, Showa University

• Nagata Kazuhiro

  School of Engineering, Tokyo Institute of Technology

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