METABOLIC ACTIVATION OF Δ^8-THTRAHYDROCANNABINOL (Δ^8-THC) AT THE 7-POSITION AND MECHANISM OF THE OXIDATION OF 7-HYDROXY-Δ^8-THC TO 7-OXO-Δ^8-THC WITH LIVER MICROSOMES
スポンサーリンク
概要
著者
-
中村 紳一郎
Specialty Chemicals Research Center Shin-etsu Chemical Co. Ltd.
-
YOSHIMURA HIDETOSHI
Faculty of Pharmaceutical Sciences, Kyushu University
-
YAMAMOTO Ikuo
School of Pharmaceutical Sciences, Kyushu University of Health and Welfare
-
Yamamoto Ikuo
北陸大学 薬 衛化
-
Nakamura S
Specialty Chemicals Research Center Shin-etsu Chemical Co. Ltd.
-
WATANABE KAZUHITO
School of Pharmacy, Hokuriku University
-
NARIMATSU SHIZUO
School of Pharmacy, Hokuriku University
-
MATSUBARA KAZUHIKO
School of Pharmacy, Hokuriku University
-
SHIMONISHI TATSUYUKI
School of Pharmacy, Hokuriku University
-
Nakamura Satoko
Osaka University Of Pharmaceutical Sciences
-
Yoshimura Hidetoshi
Faculty Of Pharmaceutical Sciences Kyushu University
-
Watanabe Kazuhito
Faculty Of Pharmaceutical Sciences Kyushu University
-
Matsubara Kazuhiko
School Of Pharmacy Hokuriku University
-
Yamamoto Ikuo
School Of Pharmaceutical Sciences Kyushu University Of Health And Welfare
-
Shimonishi Tatsuyuki
School Of Pharmacy Hokuriku University
関連論文
- Effect of Psychotropic Drugs on the 21-Hydroxylation of Neurosteroids, Progesterone and Allopregnanolone, Catalyzed by Rat CYP2D4 and Human CYP2D6 in the Brain(Biochemistry)
- FURTHER STUDIES ON SULFOXIDE-REDUCING ENZYME SYSTEM
- STUDIES ON ENZYMIC REDUCTION OF NITRO COMPOUNDS
- COMPOSITION AND PROPERTIES OF SULFOXIDE-REDUCING ENZYME SYSTEMS
- SULFOXIDE-REDUCING ENZYME SYSTEMS
- METABOLISM IN VITRO OF SULINDAC. SULFOXIDE-REDUCING ENZYME SYSTEMS IN GUINEA PIG LIVER
- STUDIES ON METABOLIC ACTIVATION OF NITROFURANS : FORMATION OF ACTIVE METABOLITES AND THEIR BINDING TO CYSTEINE AND GLUTATHIONE
- RELATIONSHIP BETWEEN BIOLOGICAL ACTIVITIES AND ENZYMATIC REDUCTION OF NITROFURAN DERIVATIVES
- Effect of Several Cellulosic Binders on Particle Size Distribution in Fluidized Bed Granulation
- Effect of Several Cellulosic Binders on Particle Size Distribution of Granules Prepared by a High-Speed Mixer
- Pharmacologica Efects in Mice of Anandamide and Its Related Fatty Acid Ethanolamides, and Enhancement of Cataleptogenic Effect of Anandamide by Phenylmethylsulfonyl Fluoride
- Site-Selective Oxidation of Strychnine by Phenobarbital Inducible Cytochrome P-450
- SITE-SELECTIVE OXIDATION OF STRYCHNINE BY PHENOBARBITAL INDUCIBLE CYTOCHROME P-450
- Species Difference in Metabolism of Strychnine with Liver Microsomes of Mice, Rats, Guinea Pigs, Rabbits and Dogs
- METABOLIC FATE OF STRYCHNINE IN VITRO
- Determination of Heavy Metal Contents in Human Gallstones Using X-Ray Fluorescence Spectrometry (Regular Presentations) (Proceedings of the 15 th Symposium on Environmental Pollutants and Toxicology)
- Determination of Metal Contents in River Sediment Near a Closed Mine by X-ray Fluorescence Spectrometry (Proceedings of the 14th Symposium on Environmental Pollutants and Toxicology)
- Determination of Metal Contents in Biological and Environmental Materials by Energy-Dispersive X-Ray Fluorescence Analysis
- MECHANISM OF SLEEP-PROLONGATING EFFECT OF Δ^8-TETRAHYDROCANNABINOL (Δ^8-THC) AND ITS METABOLITES
- IDENTIFICATION AND DETERMINATION OF 11-OXO-Δ^8-TETRAHYDROCANNABINOL AS AN INTERMEDIATE METABOLITE OF Δ^8-TETRAHYDROCANNABINOL IN THE MOUSE BRAIN AND LIVER
- UDP-GLUCURONYLTRANSFERASE ACTIVITIES OF RABBIT LIVER MICROSOMES FOR CANNABINOIDS
- METABOLIC CONVERSION OF Δ^8-TETRAHYDROCANNABINOL (Δ^8-THC) TO Δ^8-THC-11-OIC ACID AND ITS PHARMACOLOGICAL IMPLICATIONS
- METABOLISM OF 11-HYDROXY-Δ^8-THC TO 11-OXO-Δ^8THC IN RATS (The Fourth Meeting for the Study of Toxic Effect)
- Mechanism of Hepatic Microsomal Oxidation of 11-Hydroxy-Δ^8-tetra-hydrocannabinol to 11-Oxo-Δ^8-tetrahydrocannabinol. Evidence for Hydration of the Aldehyde Formed
- Inhibitory Effect of Cannabidiol Hydroxy-quinone, and Oxidative Product of Cannabidiol, on the Hepatic Microsomal Drug-Metabolizing Enzymes of Mice
- INTERACTION OF CANNABINOIDS WITH HEPATIC MICROSOMAL DRUG-METABOLIZING ENZYME SYSTEM IN THE RAT
- PURIFICATION AND CHARACTERIZATION OF MOUSE HEPATIC MICROSOMAL ALDEHYDE OXYGENASE
- MECHANISM OF CANNABIELSOIN FORMATION FROM CANNABIDIOL, ONE OF THE MAJOR CMPONENTS OF MARIHUANA
- CYTOCHROME P450 ISOZYMES INVOLVED IN METABOLIC ACTIVATION OF Δ^9-TETRAHYDROCANNABINOL BY RAT LIVER MICROSOMES
- Mechanism of Biological Formation of Cannabielsoin from Cannabidiol in the Guinea-Pig, Mouse, Rat and Rabbit
- HEPATIC MICROSOMAL OXYGENATION OF METHYL GROUP TO CARBOXYLIC ACID IN XENOBIOTICS : METABOLISM OF Δ^8-TETRAHYDROCANNABINOL AT THE 11-POSITION
- Identification of Cannabielsoin, a New Metabolite of Cannabidiol Formed by Guinea-Pig Hepatic Microsomal Enzymes, and Its Pharmacological Activity in Mice
- IN VIVO EFFECTS OF TETRAHYDROCANNABINOLS AND THEIR EIGHT MONOOXYGENATED METABOLITES ON THE HEPATIC MICROSOMAL DRUG-METABOLIZING ENZYME SYSTEMS OF MICE
- METABOLIC ACTIVATION OF CANNABIDIOL BY HEPATIC MICROSOMES. COMPLEX FORMATION WITH CYTOCHROME P-450
- MECHANISM OF THE PROLONGATION OF BARBITURATE-INDUCED SLEEPING TIME AND THE INHIBITION OF THE HEPATIC MICROSOMAL DRUG METABOLIZING ENZYMES BY CANNABIDIOL, A COMPONENT OF CANNABIS
- EFFECTS OF TWO CANNABINOIDS ON HEPATIC MICROSOMAL CYTOCHROME P-450
- METABOLIC ACTIVATION OF Δ^8-THTRAHYDROCANNABINOL (Δ^8-THC) AT THE 7-POSITION AND MECHANISM OF THE OXIDATION OF 7-HYDROXY-Δ^8-THC TO 7-OXO-Δ^8-THC WITH LIVER MICROSOMES
- METABOLIC DISPOSITION OF 8α, 9α-AND 8β, 9β-EPOXYHEXAHYDROCANNABINOLS IN THE MOUSE
- IN VITRO METABOLISM OF TETRAHYDROCANNABINOL (THC) BY HUMAN LIVER MICROSOMES. EPOXIDE-DIOL PATHWAY OF THC
- DIFFERENCE IN EPOXIDES FORMATION AND THEIR FURTHER METABOLISM BETWEEN Δ^9 -AND Δ^8-TETRAHYDROCANNABINOLS BY HUMAN LIVER MICROSOMES
- THE PROPERTIES OF UDP-GLUCURONYLTRANSFERASE FOR CANNABINOIDS IN RAT LIVER MICROSOMES
- TOXICOLOGICAL ASSESSMENT OF POLYCHLORINATED DIBENZOFURANS (PCDF). I. RELATIONSHIP BETWEEN INDUCTIVE EFFECTS ON HEPATIC ENZYMES AND TOXICITIES OF PURE PCDF CONGENERS RETAINED IN YUSHO PATIENTS
- EFFECT OF LIVER S9 FROM 3,4,5,3', 4'-PENTACHLOROBIPHENYL-PRETREATED RATS ON THE MUTAGENIC ACTIVITY OF THE VARIOUS CARCINOGENS TOWARD SALMONELLA TYPHIMURIUM TA 98
- Metabolism in Vivo of 3,4,5,3', 4'-Pentachlorobiphenyl and Toxicological Assessment of the Metabolite in Rats
- Acute Toxicity and Inductive Effect on Liver Enzymes of 3,4,5,3', 4'-Pentachlorobiphenyl in Chickens (Regular Presentations) (Proceedings of the 11 th Symposium on Environmental Pollutants and Toxicology)
- STUDIES ON CIS-TRANS ISOMERIZATION OF NITROFURAN DERIVATIVES BY BACTERIAL NITROREDUCTASES
- STUDIES ON THE METABOLISM OF NITROFURAN DERIVATIVES IN BACTERIA : PROPERTIES OF CIS-TRANS ISOMERASES AND NITROREDUCTASES, AND RELATIONSHIP OF THESE ENZYMES
- STUDIES ON ENZYMIC CIS-TRANS ISOMERIZATION OF NITROTHIOPHENE AND NITROBENZENE DERIVATIVES
- Enhanced Elimination of Theophylline, Phenobarbital and Strychnine from the Bodies of Rats and Mice by Squalane Treatment
- PURIFICATION AND CHARACTERIZATION ON 3,4,5,3', 4'-PENTACHLOROBIPHENYL-INDUCIBLE CYTOCHROME P-450 IN CHICKEN LIVER
- Mechanisms of Stimulated Fecal Excretion of Polychlorinated Aromatic Hydrocarbons in Rats
- Metabolic Activation and Detoxication of Polychlorinated Biphenyls
- IN VIVO METABOLITES OF 3,4,3', 4', -TETRACHLOROBIPHENYL AND THE TOXICOLOGICAL ASSESSMENT IN RATS
- The Synthesis of Isoquinoline Alkaloid and Its Related Compounds Using Alanine Derivatives as Chiral Auxiliaries
- OXYGEN-INSENSITIVE NITROFURAN REDUCTASES IN SALMONELLA TYPHIMURIUM TA100
- ISOLATION AND IDENTIFICATION OF THE METABOLITE OF N-(5-NITRO-2-FURFURYLIDENE)-3-AMINO-2-OXAZOLIDONE (FURAZOLI-DONE)
- Induction of a High-Spin Form of Cytochrome P-450 by Highly Toxic Polychlorinated Aromatic Hydrocarbons (Proceedings of the 14th Symposium on Environmental Pollutants and Toxicology)
- Cellular Uptake of 2,3,4,7,8-Pentachlorodibenzofuran in the Rat Liver (Proceedings of the 12 th Symposium on Environmental Pollutants and Toxicology) (Regular Presentations)
- ACCUMULATION, EXCRETION AND EFFECTS ON HEPATIC ENZYMES OF POLYCHLORINATED QUATERPHENYL CONGENERS IN RATS
- Intracellular Distribution and Binding to Cytosolic Protein of 2,3,4,7,8-Pentachlorodibenzofuran in the Liver of Rats (Regular Presentations) (Proceedings of the 11 th Symposium on Environmental Pollutants and Toxicology)
- HIGH ACCUMULATION OF 2,3,4,7,8-PENTACHLORODIBENZOFURAN TO HEPATIC MICROSOMES OF RATS
- Extremely High Affinity of 2,3,4,7,8-Pentachlorodibenzofuran for Hepatic Microsomes of Rats (Regular Presentations) (Proceedings of the 10 th Symposium on Environmental Pollutants and Toxicology)
- Effect of 3-Methylcholanthrene-and Phenobarbital-Type Polychlorinated Biphenyls (PCBs) on the Liver Soluble Enzymes of Rats (Regular Presentations) (Proceedings of the 9th Symposium on Environmental Pollutants and Toxicology)
- Enhancement of Reduction Activity of 4NQO in Animals pretreated with 3-Methylcholanthrene-type PCB and PCDF (Regular Presentations) (Proceedings of the 8th Symposium on Environmental Pollutants and Toxicology)
- Establishment by Adriamycin Exposure of Multidrug-resistant Rat Ascites Hepatoma AH130 Cells Showing Low DT-diaphorase Activity and High Cross Resistance to Mitomycins
- Inhibition of P-Glycoprotein-Dependent Multidrug Resistance by an Isoquinolinesulfonamide Compound H-87 in Rat Ascites Hepatoma AH66 Cells
- Enzymatic Hydroxylation of Tetrachlorobiphenyls in Rats
- Metabolism in Vitro of 3,4,3', 4'- and 2,5,2', 5'-Tetrachlorobiphenyl by Rat Liver Microsomes and Highly Purified Cytochrome P-450
- Liver Cytochrome P-450 Isozyme Responsible for the Metabolism of Tetrachlorobiphenyls in Rat (Proceedings of the 16 th Symposium on Environmental Pollutants and Toxicology)
- Inhibition of Cytochrome P-448H Dependent Catalytic Activity by 3,4,5,3', 4'-Pentachlorobiphenyl (Regular Presentations) (Proceedings of the 15 th Symposium on Environmental Pollutants and Toxicology)
- EFFECT OF CO-ADMINISTRATION OF INTERFERON INDUCER, POLYRIBOINOSINIC ACID-POLYRIBOCYTIDYLIC ACID, WITH SKF 525-A ON HEPATIC DRUG METABOLIZING ENZYMES OF RATS
- SUPPRESSIVE MECHANISM OF INTERFERON INDUCER, POLYRIBOINOSINIC ACID-POLYRIBOCYTIDYLIC ACID, ON THE INDUCTION OF CYTOCHROME P-450 IN RAT LIVER MICROSOMES
- SUPPRESSIVE EFFECT OF INTERFERON INDUCER, POLYRIBOINOSINIC ACID-POLYRIBOCYTIDYLIC ACID ON INDUCTION OF URIDINE DIPHOSPHATE-GLUCURONYLTRANSFERASES AND MONOOXYGENASES IN LIVER MICROSOMES OF RATS
- UNIQUE INDUCTION OF CYTOCHROME P-450 ISOZYMES IN RAT LIVER MICROSOMES BY TREATMENT WITH 3,4,5,3', 4'-PENTACHLOROBIPHENYL AND ITS EFFECT ON TESTOSTERONE METABOLISM
- EFFECT OF COBALTOUS CHLORIDE-TREATMENT ON DRUG METABOLIZING ENZYMES AND TOXICITES INDUCED BY METHYLCHOLANTHRENE-TYPE PCB
- SUPPRESSION BY INTERFERON INDUCER ON INDUCTION OF MONOOXYGENASES AND UDP-GLUCURONYLTRANSFERASES IN LIVER MICROSOMES OF RATS
- CORRELATION BETWEEN A UNIQUE CHANGE OF STEROID METABOLISM AND CYTOCHROME P-450 INDUCED BY PRETREATMENT WITH 3-METHYLCHOLANTHRENE-TYPE PCB AND PCDF
- SUPPRESSION OF THE INDUCTION OF RAT LIVER MONOOXYGENASES AND UDP-GLUCURONYLTRANSFERASES BY HEMATIN AND COBALTOUS CHLORIDE
- MECHANISM OF TOXICITY PRODUCED BY 3-METHYLCHOLANTHRENE-TYPE PCBS (2) : EFFECTS OF PCBS AND RELATED COMPOUNDS ON THE METABOLISM OF STEROIDS
- NOVEL COLUMN CHROMATOGRAPHY PROCEDURE FOR THE PURIFICATION OF UDP-GLUCURONYLTRANSFERASES
- EFFECT OF ENDOTOXIN ON INDUCTION OF MONOOXYGENASES AND UDP-GLUCURONYLTRANSFERASES IN RAT HEPATIC MICROSOMES
- A Novel Series of Thromboxane A_2 Synthetase Inhibitors with Free Radical Scavenging and Anti-peroxidative Activities
- Bioavailable Acyl-CoA : Cholesterol Acyltransferase Inhibitor with Anti-peroxidative Activity : Synthesis and Biological Activity of Novel Indolinyl Amide and Urea Derivatives
- Studies on the Constituents of Broussonetia Species. V. Two New Pyrrolidine Alkaloids, Broussonetines K and L, as Inhibitors of Glycosidase, from Broussonetia Kazinoki SIEB.
- Reductive Dimerization of Alkylidenemalonates Using Samarium(II) Diiodide and ^1H-NMR Behavior of the Dimers, 2,3-Diaryl-1,1,4,4-butanetetracarboxylates
- Species Difference of Site-Selective Glucuronidation of Morphine
- Species Difference in Codeine Uridine Diphosphate-Glucuronyltransferase Activity of Liver Microsomes
- SPECIES DIFFERENCE OF SITE-SELECTIVE GLUCURONIDATION OF MORPHINE
- DECREASED URINARY EXCRETION OF THIAMINE PROPYL DISULFIDE METABOLITES IN PATIENTS WITH LIVER DISEASE
- INHIBITORY EFFECT OF CANNABIDIOL ON THE HEPATIC MICROSOMAL DRUG-METABOLIZING ENZYME SYSTEM IN THE RAT
- Studies on the Constituents of Broussonetia Species. IV. Two New Pyrrolidinyl Piperidine Alkaloids, Broussonetines I and J, from Broussonetia kazinoki SIEB.
- Studies on the Constituents of Broussonetia Species. III. Two New Pyrrolidine Alkaloids, Broussonetines G and H, as Inhibitors of Glycosidase, from Broussonetia kazinoki SIEB.
- Studies on the Constituents of Broussonetia Species. II. Six New Pyrrolidine Alkaloids, Broussonetine A, B, E, F and Broussonetinine A and B, as Inhibitors of Glycosidases from Broussonetia kazinoki SIEB.
- A UNIQUE CHANGE OF STEROID METABOLISM IN RAT LIVER MICROSOMES INDUCED WITH HIGHLY TOXIC POLYCHLORINATED BIPHENYL(PCB) AND POLYCHLORINATED DIBENZOFURAN(PCDF)
- CHEMICAL ANALYSIS AND TOXICITY OF POLYCHLORINATED BIPHENYLS AND DIBENZOFURANS IN RELATION TO YUSHO
- DIFFERENT RESPONSIVENESS OF HEPATIC AND PULMONARY MICROSOMAL MIXED FUNCTION OXIDASES TO PHENOBARBITALTYPE AND 3-METHYLCHOLANTHRENE-TYPE POLYCHLORINATED BIPHENYLS IN RATS
- TOLERANCE DEVELOPMENT TO HYPOTHERMIC EFFECT OF Δ^8-TETRAHYDROCANNABINOL AND ITS ACTIVE METABOLITES
- METABOLIC DISPOSITION OF 8α, 9α- AND 8β, 9β-EPOXYHEXAHYDROCANNABINOL (EHHC) IN THE MOUSE
- 9α, 10α-EPOXYHEXAHYDROCANNABINOL FORMATION FROM Δ^9-TETRAHYDROCANNABINOL BY LIVER MICROSOMES OF PHENOBARBITAL-TREATED MICE AND ITS PHARMACOLOGICAL ACTIVITIES IN MICE
- IN VITRO METABOLIC FORMATION OF 8α, 9α-EPOXYHEXAHYDROCANNABINOL AND ITS IMPLICATION IN THE PHARMACOLOGICAL ACTIVITY OF Δ^8-TETRAHYDROCANNABINOL