Species Difference in Codeine Uridine Diphosphate-Glucuronyltransferase Activity of Liver Microsomes
スポンサーリンク
概要
- 論文の詳細を見る
Species difference in codeine uridine diphosphate-glucuronyltransferase (UDPGT) activity was studied in liver microsones of mice, rats, guinea pigs and rabbits. Codeine UDPGT activity was the highest in guinea pigs, followed by that in rabbits, and the lowest in mice and rats among these four animal species. The specific activities of codeine UDPGT in liver microsomes were not correlated well with those toward morphine, 4-nitrophenol, and 4-hydroxybiphenyl in liver microsomes of each of the species. Inducibility of liver microsomal codeine UDPGT activity in rats was examined by pretreatment with phenobarbital and 3-methylcholanthrene and compared with those of other UDPGT activities. The activity was inducible by phenobarbital pretreatment as the activity toward morphine and 4-hydroxybiphenyl. The inducibility of codeine UDPGT activity by phenobarbital pretreatment was not as high as that of morphine UDPGT activity.
- 公益社団法人日本薬学会の論文
著者
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Nokihara Hiroshi
Thoracic Oncology Division National Cancer Center Hospital National Cancer Center
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Nokihara Hiroshi
国立がんセンター中央病院 呼吸器グループ
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Niki Hisae
国立がんセンター中央病院 消化器内科
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YOSHIMURA HIDETOSHI
Faculty of Pharmaceutical Sciences, Kyushu University
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OGURI Kazuta
Faculty of Pharmaceutical Sciences, Kyushu University
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HANIOKA NOBUMITSU
Faculty of Pharmaceutical Sciences, Kyushu University(Present)
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Hanioka Nobumitsu
Faculty Of Pharmaceutical Sciences Kyushu University
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Hanioka Nobumitsu
Faculty Of Pharmaceutical Sciences Kyushu University(present):national Institute Of Hygienic Science
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Yoshimura Hidetoshi
Faculty Of Pharmaceutical Sciences Kyushu University
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Yoshimura Hidetoshi
Faculty Of Pharmaceutical Sciences Kyushu University(present):department Of Food And Nutrition Nakam
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Oguri Kazuta
Faculty Of Pharmaceutical Sciences Kyushu University
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Oguri K
Faculty Of Pharmaceutical Sciences Kyushu University
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Oguri K
Kyushu Univ. Fukuoka Jpn
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HOSHIKAWA Youichi
Faculty of Pharmaceutical Sciences, Kyushu University
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MITSUI Tetsuya
Faculty of Pharmaceutical Sciences, Kyushu University
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Mitsui Tetsuya
Faculty Of Pharmaceutical Sciences Kyushu University
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Yoshimura H
Faculty Of Pharmaceutical Sciences Kyushu University(present):department Of Food And Nutrition Nakam
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Matsunaga Tamihide
Faculty Of Pharmaceutical Sciences Kyushu University
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