METABOLISM IN VITRO OF SULINDAC. SULFOXIDE-REDUCING ENZYME SYSTEMS IN GUINEA PIG LIVER
スポンサーリンク
概要
- 論文の詳細を見る
The sulfoxide reduction of sulindac (cis-5-fluoro-2-methyl-1-[p-(methylsulfinyl)-benzylidenyl] indene-3-acetic acid), an anti-inflammatory agent, was demonstrated in vitro by cell-free preparations of guinea pig liver. The sulfoxide reductase activity was located in both fractions of microsomes and 105000×g supernatant. The microsomal reductase was NADPH-or NADH-dependent, and required the factor present in the soluble fraction for its activity. The factor was heat-labile and non-dialyzable. Furthermore, a pattial purification of the microsomal NADPH-cytochrome c reductase resulted in a paralleled increase of the sulfoxide reductase activity. The present observations suggest that the soluble factor described above functions as an electron transfer component coupled with NADPH-cytochrome c reductase.
- 社団法人日本薬学会の論文
著者
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Tatsumi Kiyoshi
Institute Of Pharmaceutical Sciences Hiroshima University School Of Medicine
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Kitamura Shigeyuki
Faculty Of Pharmaceutical Sciences Kyushu University
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TATSUMI KIYOSHI
Faculty of Pharmaceutical Sciences, Kyushu University
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YOSHIMURA HIDETOSHI
Faculty of Pharmaceutical Sciences, Kyushu University
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Yoshimura Hidetoshi
Faculty Of Pharmaceutical Sciences Kyushu University
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Tatsumi Kiyoshi
Faculty Of Pharmaceutical Sciences Kyushu University:(present Address)institute Of Pharmaceutical Sc
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