EFFECT OF LIVER S9 FROM 3,4,5,3', 4'-PENTACHLOROBIPHENYL-PRETREATED RATS ON THE MUTAGENIC ACTIVITY OF THE VARIOUS CARCINOGENS TOWARD SALMONELLA TYPHIMURIUM TA 98

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Effects of liver 9000×g supernatant fraction from 3,4,5,3', 4'-pentachlorobipheny- and 2,4,5,2', 4', 5'-hexachlorobiphenyl-pretreated rats (PenCB-S9 and HexCB-S9,respectively) on the mutagenic activities of well-known carcinogens, benzo [a] pyrene (BP), Glu-P-1 (2-amino-6-methyldipyrido [1,2-a : 3', 2'-d] imidazole), Trp-P-1(3-amino-1,4-dimethyl-5H-pyrido [4,3-b] indole), and aflatoxin B_1 (AFB), toward Salmonella typhimurium TA 98 have been described. Although the mutagenic activities of all of these carcinogens were enhanced by these S9,PenCB-S9 sepecially highly activated BP, Glu-P-1,and Trp-P-1. The ability of PenCB--S9 to activate the carcinogens was much higher than that of liver 9000×g supernatant fraction from 3-methylcholanthrene-pretreated rats (MC-S9). PenCB-S9 enhanced the mutagenic activity of BP 8 times higher than MC-S9,while Glu-P-1 and Trp-P-1 were activated by PenCB-S9 twice as much as by MC-S9. Effect of HexCB--S9 on the mutagenic activities of the above-mentioned three carcinogens was much less than those of PenCB- and MC-S9 and a little higher than that of 9000×g supernatant fraction from rats pretreated with phenobarbital. As for AFB, phenobarbital was the most potent inducer, and HexCB and PenCB were next to this. Data suggest that PenCBis a strong inducer of P-448 species which activate environmental toxicants.
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