DIFFERENT RESPONSIVENESS OF HEPATIC AND PULMONARY MICROSOMAL MIXED FUNCTION OXIDASES TO PHENOBARBITALTYPE AND 3-METHYLCHOLANTHRENE-TYPE POLYCHLORINATED BIPHENYLS IN RATS
スポンサーリンク
概要
- 論文の詳細を見る
Inductive effects of pretreatments with a phenobarbital(PB)-type 2,4,5,2', 4', 5', -hexachlorobiphenyl(HCB), a 3-methylcholanthrene(MC)-type 3,4,5,3', 4', -pentachlorobiphenyl(PenCB) and a mixed type polychlorinated biphenyl (PCB) mixture, Kanechlor(KC-)400 as well as PB and MC on the hepatic and pulmonary microsomal mixed function oxidases(MFOs) were examined and compared using male Wistar rats. Hepatic cytochrome P-450(448) content was increased 2-to 4-fold by pretteatment with all inducers tested, whereas the pulmonary content was slightly elevated only by the MC-type (MC and PenCB) and mixed type inducers. Benzphetamine(BZ) N-demethylase activity in the liver was strongly enhanced by the PB-type (PB and HCB) and mixed type inducers, but not affected by MC and suppressed by PenCB. Pulmonary BZN-demethylation was not affected by pretreatments with the MC-type and mixed type inducers while both PB-type inducers decreased the activity.The PB-type inducers, showing a weak inducibility for aryl hydrocarbon hydroxylase (AHH) in the liver, also diminished the activity in the lung. In contrast, a marked enhancement of AHH activity in both organs was caused by pretreatment with the MC-type and mixed type inducers. AHH activity in both organs from PenCB-treated rats was highly sensitive to α-naphthoflavone but almost insensitive to SKF 525-A. These results strongly suggest that the pulmonary MFO in rats in inducible only with MC-type but not with PB-type PCB unlike the hepatic MFO.
- 公益社団法人日本薬学会の論文
著者
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Nagata Kiyoshi
九州大学 薬
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Nagata Kiyoshi
Faculty Of Pharmaceutical Sciences Kyushu University
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YOSHIMURA HIDETOSHI
Faculty of Pharmaceutical Sciences, Kyushu University
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Yoshimura Hidetoshi
Faculty Of Pharmaceutical Sciences Kyushu University
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Yoshihara Shinchi
Faculty Of Pharmaceutical Sciences Kyushu University
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Yoshihara Shinichi
Faculty Of Pharmaceutical Sciences Kyushu University
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Yoshihara S
Department Of Xenobiotic Metabolism And Molecular Toxicology Graduate School Of Biomedical Science H
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Yoshimura H
Faculty Of Pharmaceutical Sciences Kyushu University(present):department Of Food And Nutrition Nakam
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Nagata K
Faculty Of Pharmaceutical Sciences Kyushu University
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Yoshihara Shinichi
Faculty Of Pharmaceutical Sciences Kyushu University:(present Address)institute Of Pharmaceutical Sc
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