Estrogenic Potency of a Bisphenol A Metabolite on Vitellogenin Synthesis in Medaka, Oryzias latipes
スポンサーリンク
概要
- 論文の詳細を見る
We investigated the estrogenic activity of a bisphenol A (BPA) metabolite (4-methyl-2,4-bis(p-hydroxyphenyl)-pent-1-ene; MBP) in male medaka (Oryzias latipes) using vitellogenin (Vg, Vg1 and Vg2) as a biomarker. Male d-rR medaka were exposed to various concentrations of estradiol-17β (E2), MBP and BPA for 3 days, and then the serum Vg concentration was measured using specific chemiluminescent immunoassays. The estimated relative estrogenic activities of MBP and BPA compared with E2 (100%) were 1.3-1.4% and 0.00010-0.00023%, respectively. These findings indicated that MBP has about 104-fold higher estrogenic potency than the parent BPA and about 1/50 that of E2 for Vg synthesis in medaka. This is the first study to show that MBP can act as a highly potent estrogen agonist in living organisms.
- 公益社団法人日本薬学会の論文
- 2005-02-01
著者
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TAKAO Yuji
Faculty of Environmental Studies, Nagasaki University
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ARIZONO Koji
Environmental and Symbiotic Sciences, Prefectural University of Kumamoto
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ARIZONO Koji
Faculty of Environmental and Symbiotic Sciences, Prefectural University of Kumamoto
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Kohra Shinya
Faculty of Environmental Studies, Nagasaki University
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Tominaga Nobuaki
Department of Chemical and Biological Engineering, Ariake National College of Technology
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Hara Akihiko
Division Of Marine Bioscience Graduate School Of Fisheries Science
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Kohra Shinya
Faculty Of Environmental Studies Nagasaki University
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Kohra Shinya
Faculty Of Liberal Arts Nagasaki University
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Arizono K
Prefectural Univ. Kumamoto Kumamoto Jpn
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Arizono Koji
Environmental And Symbiotic Sciences Prefectural University Of Kumamoto
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Arizono K
Faculty Of Pharmaceutical Sciences Nagasaki University
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Arizono Koji
Faculty Of Environment Studies Nagasaki University
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Soyano K
Nagasaki Univ. Nagasaki
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Soyano Kiyoshi
Institute For East China Sea Research Nagasaki University
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Soyano Kiyoshi
Graduate School Of Science And Technology
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Takao Y
Faculty Of Environmental Studies Nagasaki University
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Takao Yuji
Faculty Of Environmental Studies Nagasaki University
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冨永 伸明
Department Of Chemical And Biological Engineering Ariake National College Of Technology
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Nagae Masaki
Faculty of Environmental Studies, Nagasaki University
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Ishibashi Yasuhiro
Faculty of Human Environment, Nagasaki Institute of Applied Science
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Ishibashi Yasuhiro
Environmental Protection Center, Nagasaki University
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Saito Koji
Division Of Marine Biosciences Graduate School Of Fisheries Sciences Hokkaido University
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Tominaga Nobuaki
Department Of Biochemistry School Of Pharmaceutical Sciences Nagasaki University
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Yoshihara Shinchi
Faculty Of Pharmaceutical Sciences Kyushu University
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Nagae M
Faculty Of Environmental Studies Nagasaki University
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Nagae Masaki
Faculty Of Environmental Studies Nagasaki University
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Yoshihara Shinichi
Faculty Of Pharmaceutical Sciences Kyushu University
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Yoshihara S
Department Of Xenobiotic Metabolism And Molecular Toxicology Graduate School Of Biomedical Science H
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Inoue Mihoka
Division of Marine Bioscience, Graduate School of Fisheries Science
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Ishibashi Yasuhiro
Faculty Of Human Environment Nagasaki Institute Of Applied Science
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Ishibashi Yasuhiro
Environmental Protection Center Nagasaki University
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Inoue Mihoka
Division Of Marine Bioscience Graduate School Of Fisheries Science
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Tominaga Nobuaki
Dep. Of Chemical And Biological Engineering Ariake National Coll. Of Technol.
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Kohra S
Faculty Of Environmental Sciences Nagasaki University
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Ishibashi Yasuhiro
Environmental Protection Center
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Takao Yuji
Faculty of Environmental Sciences
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Kohra Shinya
Faculty of Environmental Sciences
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