The Potential Contribution of Phytoestrogens and Organochlorine Pesticides in an Experimental Fish Diet to Estrogenic Activity
スポンサーリンク
概要
- 論文の詳細を見る
Phytoestrogens and organochlorine pesticides in the diet of laboratory animals are a possible source of interference in bioassays that assess estrogenic activity. In the present study, we investigated the levels of dietary phytoestrogens, organochlorine pesticides and the estrogenic activity of various diets for an experimental fish and discuss the potential contribution of these substances to estrogenic activity, in comparison with those used in previous studies. After hydrolysis with β-glucuronidase, genistein and daidzein were detected in all of the diets, and there were no significant differences in the contents of these substances among present and previous investigations. In addition, organochlorine pesticides, such as hexachlorobenzene (HCB), β-benzene hexachloride (β-BHC), γ-BHC, trans-nonachlor, and/or endrin, were detected in most fish diets. All of these diets exhibited higher levels of activation of β estrogen receptors than with α estrogen receptors in an in vitro yeast-based bioassay. These results indicate that phytoestrogens, such as genistein and daidzein, were the main substances contributing to the estrogenic activity of the diet. Moreover, some diets may exert estrogenic activity in in vivo tests, indicating the necessity for more careful selection of the feeding diet and measurement of estrogenic substances when performing routine screening assays for endocrine-disrupting chemicals.
- 公益社団法人日本薬学会の論文
- 2005-04-01
著者
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ARIZONO Koji
Environmental and Symbiotic Sciences, Prefectural University of Kumamoto
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ARIZONO Koji
Faculty of Environmental and Symbiotic Sciences, Prefectural University of Kumamoto
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石橋 康弘
Environmental And Symbiotic Sciences Prefectural University Of Kumamoto
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Ishibashi Hiroshi
Faculty Of Engineering Yokohama National University
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Arizono K
Prefectural Univ. Kumamoto Kumamoto Jpn
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Arizono Koji
Environmental And Symbiotic Sciences Prefectural University Of Kumamoto
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Arizono K
Faculty Of Pharmaceutical Sciences Nagasaki University
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Arizono Koji
Faculty Of Environment Studies Nagasaki University
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Honda Eiko
Faculty Of Environmental And Symbiotic Sciences Prefectural University Of Kumamoto
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Ishibashi Yasuhiro
Faculty of Human Environment, Nagasaki Institute of Applied Science
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MATSUOKA Munekazu
Faculty of Environmental and Symbiotic Sciences, Prefectural University of Kumamoto
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Ushijima Marie
Faculty of Engineering, Sojo University
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Inudo Makiko
Faculty of Environmental and Symbiotic Sciences, Prefectural University of Kumamoto
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Iwahara Masayoshi
Faculty of Engineering, Sojo University
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Cho Hyeon
Yosu National University, Division of Ocean System
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Ishibashi Yasuhiro
Environmental Protection Center, Nagasaki University
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Cho Hyeon
Yosu National University Division Of Ocean System
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Inudo Makiko
Faculty Of Environmental And Symbiotic Sciences Prefectural University Of Kumamoto
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Inudo Makiko
Faculty Of Engineering Kyushu Institute Of Technology
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Ushijima Marie
Faculty Of Engineering Sojo University
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Ishibashi Hiroshi
Graduate School Of Science And Technology Nagasaki University
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Ishibashi Yasuhiro
Faculty Of Human Environment Nagasaki Institute Of Applied Science
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Ishibashi Yasuhiro
Environmental Protection Center Nagasaki University
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Iwahara Masayoshi
Faculty Of Engineering Sojo University
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Matsuoka Munekazu
Faculty Of Environmental And Symbiotic Sciences Prefectural University Of Kumamoto
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Cho Hyeon-Seo
Yosu National University, Division of Ocean System
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Ishibashi Yasuhiro
Environmental Protection Center
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