EFFECTS OF MATERNAL ETHANOL INTAKE DURING PREGNANCY ON FETAL AND MATERNAL LIVER ENZYME SYSTEMS IN WISTAR RATS
スポンサーリンク
概要
- 論文の詳細を見る
In the present study, the effects of maternal ethanol intake during pregnancy on microsomal cytochrome contents and on enzyme activities in the developing fetus were investigated. Ethanol intake to pregnant females did not affect the maternal body weight or number of fetuses, but tended to reduce the mean fetal body weight, especially the fetuses from a litter of mother who were treated with ethanol during day zero to 20 of gestation showed significant decreases in the body and liver weights. No significant changes were observed in the contents of cytochrome P-450 and b_5 and the activities of NADPH-cytochrome c reductase and heme oxygenase in the livers of fetuses whose mothers were exposed to ethanol during pregnancy when compared with that of untreated pregnant rats. However, NADH-cytochrome b_5 reductase activity in the fetal livers was found to significantly decrease by maternal ethanol intake during pregnancy.
- 公益社団法人日本薬学会の論文
著者
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ARIZONO Koji
Faculty of Environmental and Symbiotic Sciences, Prefectural University of Kumamoto
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Arizono Koji
Faculty Of Pharmaceutical Sciences Nagasaki University
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Arizono Koji
Faculty Of Environment Studies Nagasaki University
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YAMAGUCHI Masahiro
Faculty of Science, Ehime University
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ARIYOSHI TOSHIHIKO
Faculty of Pharmaceutical Sciences, Nagasaki University
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TERADA NAOKATA
Faculty of Pharmaceutical Sciences, Nagasaki University
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NAKAI TETSUYA
Faculty of Pharmaceutical Sciences, Nagasaki University
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HATTA AKIRA
Faculty of Pharmaceutical Sciences, Nagasaki University
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Ariyoshi Toshihiko
Faculty Of Pharmaceutical Sciences Nagasaki University
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Nakai Tetsuya
Faculty Of Pharmaceutical Sciences Nagasaki University
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Terada Naokata
Faculty Of Pharmaceutical Sciences Nagasaki University
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Hatta Akira
Faculty Of Pharmaceutical Sciences Nagasaki University
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Yamaguchi Masahiro
Faculty Of Pharmaceutical Sciences Nagasaki University
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YAMAGUCHI MASAHIRO
Faculty of Pharmaceutical Sciences, Nagasaki University
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