ACUTE EFFECT OF METHAMPHETAMINE ON HEME OXYGENASE ACTIVITY AND ON CYTOCHROME P-450 CONTENT IN THE LIVER OF FEMALE RATS
スポンサーリンク
概要
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After a single treatment with d-methamphetamine (philopon) at a dose of 8 mg/kg in 10 weeks old female Wistar rats, heme oxygenase activity was enhanced at 3 hr and reached its peak level at 12 hr, whereas cytochrome P-450 content showed the lowest level at 12 hr. However, activity of δ-aminolevulinic acid synthetase was not affected. Twenty-four hr later, all measured parameters returned to nearly initial levels at zero time. The pretreatment with cycloheximide blocked the increase of heme oxygenase activity in philopon-treated animals.
- 公益社団法人日本薬学会の論文
著者
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ARIYOSHI TOSHIHIKO
Faculty of Pharmaceutical Sciences, Nagasaki University
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HAMASAKI KAZUHISA
Faculty of Pharmaceutical Sciences, Nagasaki University
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Ariyoshi Toshihiko
Faculty Of Pharmaceutical Sciences Nagasaki University
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Hamasaki Kazuhisa
Faculty Of Pharmaceutical Sciences Nagasaki University
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