A Rapid Respiratory Toxicity Test Using Caenorhabditis elegans with an Oxygen Electrode System

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概要

• 論文の詳細を見る

• We describe a novel approach to evaluating the respiratory toxicity of chemicals in the free-living nematode Caenorhabditis elegans. Using DOX-96KT, a general purpose, multi-channel dissolved oxygen (DO) measuring system, we measured the DO concentration in culture media containing C. elegans exposed to chemicals to assay for respiratory toxicity. The current value, which is an index of the dissolved oxygen concentration in culture media, was measured every 10 sec for 30 min at 24°C. We focused on the respiration levels of the exposed worms between 500 and 1800 sec. This method produces results that are similar to the computer tracking system measuring behavioral toxicity. Since it can do multiple dilution series tests at a given time, it is useful for concentration-activity correlation studies. This novel technique is not only an alternative to the computer tracking system for measuring behavioral toxicity but also a rapid sublethal toxicity test for chemical hazard assessment.

• 公益社団法人日本薬学会の論文
• 2002-06-01

著者

• Ueda Kazuo

  Faculty Of Environmental Sciences Nagasaki University

• Ura Kazuhiro

  有明工業高等専門学校

• Ura Kazuhiro

  Faculty Of Environmental And Symbiotic Sciences Prefectural University Of Kumamoto:crest Japan Scien

• TAKAO Yuji

  Faculty of Environmental Studies, Nagasaki University

• ARIZONO Koji

  Faculty of Environmental and Symbiotic Sciences, Prefectural University of Kumamoto

• Kohra Shinya

  Faculty of Environmental Studies, Nagasaki University

• Tominaga Nobuaki

  Department of Chemical and Biological Engineering, Ariake National College of Technology

• Kohra Shinya

  Faculty Of Environmental Studies Nagasaki University

• Kohra Shinya

  Faculty Of Liberal Arts Nagasaki University

• Arizono K

  Prefectural Univ. Kumamoto Kumamoto Jpn

• Arizono K

  Faculty Of Pharmaceutical Sciences Nagasaki University

• Arizono Koji

  Faculty Of Environment Studies Nagasaki University

• Soyano K

  Nagasaki Univ. Nagasaki

• Soyano Kiyoshi

  Institute For East China Sea Research Nagasaki University

• Soyano Kiyoshi

  Graduate School Of Science And Technology

• Takao Y

  Faculty Of Environmental Studies Nagasaki University

• Takao Yuji

  Faculty Of Environmental Studies Nagasaki University

• 冨永 伸明

  Department Of Chemical And Biological Engineering Ariake National College Of Technology

• Nagae Masaki

  Faculty of Environmental Studies, Nagasaki University

• Ishibashi Yasuhiro

  Faculty of Human Environment, Nagasaki Institute of Applied Science

• Ishibashi Yasuhiro

  Environmental Protection Center, Nagasaki University

• Saito Koji

  Division Of Marine Biosciences Graduate School Of Fisheries Sciences Hokkaido University

• Tominaga Nobuaki

  Department Of Biochemistry School Of Pharmaceutical Sciences Nagasaki University

• Nagae M

  Faculty Of Environmental Studies Nagasaki University

• Nagae Masaki

  Faculty Of Environmental Studies Nagasaki University

• Ishibashi Yasuhiro

  Faculty Of Human Environment Nagasaki Institute Of Applied Science

• Ishibashi Yasuhiro

  Environmental Protection Center Nagasaki University

• Ueda Kazuo

  Dep. Of Human Sci. Kyushu Univ.

• Ueda K

  Department Of Applied Information And Communication Sciences Kyushu University

• Ueda Kazuo

  Faculty Of Agriculture Nagoya University

• Tominaga Nobuaki

  Dep. Of Chemical And Biological Engineering Ariake National Coll. Of Technol.

• Kohra S

  Faculty Of Environmental Sciences Nagasaki University

• Ishibashi Yasuhiro

  Environmental Protection Center

• Takao Yuji

  Faculty of Environmental Sciences

• Kohra Shinya

  Faculty of Environmental Sciences

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