A Convenient Sublethal Assay of Alkylphenol and Organotin Compounds Using the Nematode Caenorhabditis elegans

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概要

• 論文の詳細を見る

• The free-living nematode, Caenorhabditis elegans (C. elegans) was adopted as a multicellular biosensor of biological toxicity from alkylphenols and organotin compounds. Alkylphenols were found to affect reproduction at lower doses than indicated by the acute toxicity assay. In particular, nonylphenol altered the reproduction rate of C. elegans at a dose 10- to 100-fold lower than the 50% lethal concentration (LC50). A comparison of the number of viable worms and eggs suggested that alkylphenols and organotin compounds possess hatching toxicity. A 0.1 μM dose of organotin compounds caused a significant decrease, in the order of 20-50%, in reproduction of the worms, and an abnormal male: hermaphrodite ratio was observed. C. elegans therefore appears to represent a potent and sensitive organism with which to evaluate the biological effects of chemicals. In particular, the sensitivity of reproduction as an endpoint is highly useful for assessing the sublethal effects of chemicals.

• 公益社団法人日本薬学会の論文
• 2002-12-01

著者

• Ueda Kazuo

  Faculty Of Environmental Sciences Nagasaki University

• Ura Kazuhiro

  有明工業高等専門学校

• Ura Kazuhiro

  Faculty Of Environmental And Symbiotic Sciences Prefectural University Of Kumamoto:crest Japan Scien

• TAKAO Yuji

  Faculty of Environmental Studies, Nagasaki University

• ARIZONO Koji

  Faculty of Environmental and Symbiotic Sciences, Prefectural University of Kumamoto

• Kohra Shinya

  Faculty of Environmental Studies, Nagasaki University

• Tominaga Nobuaki

  Department of Chemical and Biological Engineering, Ariake National College of Technology

• Kai Toshinori

  Faculty Of Environmental And Symbiotic Sciences Prefectural University Of Kumamoto

• Kai Toshinori

  Faculty Of Environmental And Symbiotic Sciences Prefectural University

• Kohra Shinya

  Faculty Of Environmental Studies Nagasaki University

• Kohra Shinya

  Faculty Of Liberal Arts Nagasaki University

• Arizono K

  Prefectural Univ. Kumamoto Kumamoto Jpn

• Arizono K

  Faculty Of Pharmaceutical Sciences Nagasaki University

• Arizono Koji

  Faculty Of Environment Studies Nagasaki University

• Soyano K

  Nagasaki Univ. Nagasaki

• Soyano Kiyoshi

  Institute For East China Sea Research Nagasaki University

• Soyano Kiyoshi

  Graduate School Of Science And Technology

• Takao Y

  Faculty Of Environmental Studies Nagasaki University

• Takao Yuji

  Faculty Of Environmental Studies Nagasaki University

• 冨永 伸明

  Department Of Chemical And Biological Engineering Ariake National College Of Technology

• Nagae Masaki

  Faculty of Environmental Studies, Nagasaki University

• Ishibashi Yasuhiro

  Faculty of Human Environment, Nagasaki Institute of Applied Science

• Ishibashi Yasuhiro

  Environmental Protection Center, Nagasaki University

• Saito Koji

  Division Of Marine Biosciences Graduate School Of Fisheries Sciences Hokkaido University

• Tomoeda Mineko

  Faculty of Environmental Sciences

• Tominaga Nobuaki

  Department Of Biochemistry School Of Pharmaceutical Sciences Nagasaki University

• Nagae M

  Faculty Of Environmental Studies Nagasaki University

• Nagae Masaki

  Faculty Of Environmental Studies Nagasaki University

• Ishibashi Yasuhiro

  Faculty Of Human Environment Nagasaki Institute Of Applied Science

• Ishibashi Yasuhiro

  Environmental Protection Center Nagasaki University

• Ueda Kazuo

  Dep. Of Human Sci. Kyushu Univ.

• Ueda K

  Department Of Applied Information And Communication Sciences Kyushu University

• Ueda Kazuo

  Faculty Of Agriculture Nagoya University

• Tominaga Nobuaki

  Dep. Of Chemical And Biological Engineering Ariake National Coll. Of Technol.

• Kohra S

  Faculty Of Environmental Sciences Nagasaki University

• Ishibashi Yasuhiro

  Environmental Protection Center

• Takao Yuji

  Faculty of Environmental Sciences

• Kohra Shinya

  Faculty of Environmental Sciences

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