Expression Analysis of Estrogen-responsive Genes Vitellogenin 1 and 2 in Liver of Male Medaka (Oryzias latipes) Exposed to Selective Ligands of Estrogen Receptor Subtypes
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概要
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Vitellogenin (VTG) is a useful biomarker for detecting the estrogenic activity of chemicals in aquatic environments. However, little information is available on the regulatory mechanisms of the expression of each VTG subtype, particularly the relationship between expression patterns of VTG1/2 and estrogen receptor (ER) subtypes, such as ERα and ERβ. In this paper, we measured VTG1 and VTG2 mRNA induction in male medaka liver, which was treated with ERα-selective ligand, (17α, 20E)-3-hydroxy-17,20-[(1-methoxyethylidene)bis(oxy)]-19-norpregna-1,3,5(10),20-tetraene-21-carboxylic acid, methyl ester or ERβ-selective ligand, 2-(4-hydroxyphenyl)-5-hydroxy-1,3-benzoxazole and investigated the characteristics of ER subtype function in VTG1 and VTG2 inductions. Hepatic VTG1 mRNA was induced by ERα-selective ligands at even low concentration and maximum increases were the same as for E2. VTG2 mRNA was also increased, but its levels were very low. On the other hand, ERβ-selective ligands significantly increased VTG2 mRNA in the presence of ERα agonists. These results indicate that the expression of each VTG subtype is regulated by unique ER subtypes. VTG1 expression is only regulated by the action of ERα. In contrast, VTG2 expression is regulated by both ERα and ERβ, with ERα being essential for VTG2 gene expression and ERβ being essential for enhancement.
著者
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Inouye Yoshio
Faculty of Pharmaceutical Sciences, Toho University
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ARIZONO Koji
Faculty of Environmental and Symbiotic Sciences, Prefectural University of Kumamoto
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Nakahama Takayuki
Faculty Of Pharmaceutical Sciences Toho University
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Inouye Yoshio
Faculty Of Pharmaceutical Sciences Toho University
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Yamaguchi Akemi
Department of Chemical and Biological Engineering, Ariake National College of Technology
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Ishibashi Hiroshi
Center for Marine Environmental Studies (CMES), Ehime University
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Kohra Shinya
Faculty of Environmental Studies, Nagasaki University
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Kato Keisuke
Faculty of Pharmaceutical Sciences, Toho University
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Kanno Yuichro
Faculty of Pharmaceutical Sciences, Toho University
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Tominaga Nobuaki
Department of Chemical and Biological Engineering, Ariake National College of Technology
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石橋 康弘
Environmental And Symbiotic Sciences Prefectural University Of Kumamoto
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Kohra Shinya
Faculty Of Environmental Studies Nagasaki University
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Kohra Shinya
Faculty Of Liberal Arts Nagasaki University
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Arizono Koji
Faculty Of Environment Studies Nagasaki University
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Soyano K
Nagasaki Univ. Nagasaki
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Soyano Kiyoshi
Institute For East China Sea Research Nagasaki University
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Soyano Kiyoshi
Graduate School Of Science And Technology
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Saito Koji
Division Of Marine Biosciences Graduate School Of Fisheries Sciences Hokkaido University
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Tominaga Nobuaki
Department Of Biochemistry School Of Pharmaceutical Sciences Nagasaki University
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Ishibashi Hiroshi
Graduate School Of Science And Technology Nagasaki University
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Yamaguchi Akemi
Department Of Chemical And Biological Engineering Ariake National College Of Technology
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Kato Keisuke
Faculty Of Pharmaceutical Sciences Toho University
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Kohra S
Faculty Of Environmental Sciences Nagasaki University
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Nakahama Takayuki
Faculty of Pharmaceutical Sciences, Toho University
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Kohra Shinya
Faculty of Environmental Sciences
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