Transcriptional Determination of Sexually Dimorphic Expression of Nuclear Receptor Constitutively Active Receptor (CAR) in Wistar Rats
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概要
- 論文の詳細を見る
The mammalian constitutively active receptor (CAR) is a ligand-activated transcription factor that participates in controlling the expression ofcytochrome P450 2B (CYP2B) genes in response to phenobarbital (PB) in rodents. CYP2B forms are highly inducible in liver and intestine in male Wistar rats. In contrast, PB-dependent increases in CYP2B activity are rarely observed in female Wistar rats. The profiles of CAR mRNA expression measured by RT-PCR in various organs in male and female Wistar rats were consistent with those of PB-dependent expression of CYP2B genes. The sex-related dimorphic PB-responses of CYP2B genes in Wistar rats might be determined transcriptionally as are the organospecific PB-responses in both males and females.
- 社団法人日本薬学会の論文
- 2004-08-01
著者
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Kanno Yuichiro
Faculty of Pharmaceutical Sciences, Toho University
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Inouye Yoshio
Faculty of Pharmaceutical Sciences, Toho University
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Mizuno Masaki
Department Of Environmental Health Faculty Of Pharmaceutical Sciences Toho University
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Mizuno Masaki
東邦大学 薬学部公衆衛生学
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Mizuno Masaki
Department Of Cardiovascular Dynamics National Cardiovascular Centre Research Institute
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Kanno Yuichiro
Department of Environmental Health, Faculty of Pharmaceutical Sciences, Toho University
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Moriyama Tomomi
Department of Environmental Health, Faculty of Pharmaceutical Sciences, Toho University
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Ichikawa Hiroyasu
Department of Environmental Health, Faculty of Pharmaceutical Sciences, Toho University
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Nakahama Takayuki
Department of Environmental Health, Faculty of Pharmaceutical Sciences, Toho University
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Inouye Yoshio
Department of Environmental Health, Faculty of Pharmaceutical Sciences, Toho University
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Nakahama Takayuki
Fac. Of Pharmaceutical Sciences Toho Univ.
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Nakahama Takayuki
Faculty Of Pharmaceutical Sciences Toho University
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Nakahama Takayuki
Faculty Of Pharmuceutical Sciences Toho University
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Inouye Yoshio
Fac. Of Pharmaceutical Sciences Toho Univ.
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Inouye Yoshio
科学警察研究所
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Inouye Y
Faculty Of Pharmuceutical Sciences Toho University
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Kanno Yuichiro
Fac. Of Pharmaceutical Sciences Toho Univ.
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MOCHIZUKI Megumi
Faculty of Pharmaceutical Sciences, Toho University
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Moriyama Tomomi
Department Of Environmental Health Faculty Of Pharmaceutical Sciences Toho University
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Nakahama Takayuki
Department Of Environmental Health Faculty Of Pharmaceutical Sciences Toho University
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Ichikawa Hiroyasu
Department Of Environmental Health Faculty Of Pharmaceutical Sciences Toho University
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Inouye Y
Faculty Of Pharmaceutical Sciences Toho University
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Mochizuki Megumi
Department Of Environmental Health Faculty Of Pharmaceutical Sciences Toho University
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Ichikawa Hiroyasu
Department of Chemistry, Faculty of Science, Kanazawa University
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