ALTERED THIAMINE PROPYL DISULFIDE METABOLISM IN RATS WITH LIVER INJURY INDUCED BY CARBON TETRACHLORIDE AND D-GALACTOSAMINE
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概要
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The urinary excretion of 2-hydroxypropyl methyl sulfone (2HPMS) and methyl propyl sulfone (MPS) after oral administration of thiamine propyl disulfide (TPD) was examined in rats with liver injury induced by carbon tetrachloride (CCl_4) and D-galactosamine (GAL), in order to investigate the effect of liver damage on TPD metabolism. In the CCl_4-treated rats, excretion of 2HPMS and MPS markedly decreased at an early stage, but MPS thereafter started to be excreted rapidly as compared with the control rats. On the other hand, 2HPMS continued to be excreted in lesser amounts in the CCl_4-treated rats in the control rats even after 72h. In the GAL-treated rats, excretion of 2HPMS and MPS did not vary so greatly at a dose of 300 mg/kg, but alteration of excretion of 2HPMS and MPS was clearly observed at a dose of 600 mg/kg and slightly more at a dose of 1200 mg/kg. In comparison with the CCl_4-treated rats, delay of MPS excreation was not observed but excretion of 2HPMS more delayed in the GAL-treated rats. Concerning the amount excreted in the 0-72 h urine, decrease in 2HPMS and increase in MPS was the same as the CCl_4-treated rats. From light microscopic examination, the liver of rats treated at a dose of 1000 mg/kg of GAL was found to be injured over a long period. Form these results, TPD metabolism was suggested to be impaired in proportion to be severity of liver damage, and decrease of 2HPMS excretion was confirmed in liver-injured rats, as well as the patients with liver disease. Our previous suggestion that measurement of 2HPMS excreted in the urine was a useful test for quantification of liver disease was supported.
- 公益社団法人日本薬学会の論文
著者
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Yoshimura Hidetoshi
Faculty Of Pharmaceutical Sciences Kyushu University
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Yamano Shigeru
Faculty Of Pharmaceutical Sciences Fukuoka University
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SHIMIZU MASANORI
School of Medicine, Fukuoka University
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Shimizu Masanori
School Of Medicine Fukuoka University
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Yamano Shigeru
Faculty of Pharmaceutical Science, Fukuoka University
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