EFFECT OF CO-ADMINISTRATION OF INTERFERON INDUCER, POLYRIBOINOSINIC ACID-POLYRIBOCYTIDYLIC ACID, WITH SKF 525-A ON HEPATIC DRUG METABOLIZING ENZYMES OF RATS
スポンサーリンク
概要
- 論文の詳細を見る
The protective effect of SKF 525-A on the suppression of cytochrome P-450 content and monooxygenase activities by treatment with CoCl_2 and polyriboinosinic acidpolyribocytidylic acid [poly (I.C)] was compared as a part of studies of suppression of drug metabolizing enzymes by interferon inducers. Induction of heme oxygenase activity by CoCl_2 and poly (I.C) was not altered by simultaneous treatment with SKF 525-A. Depression of cytochrome P-450 content and benzphetamine N-demethylase activity by treatment with CoCl_2 was prevented by co-treatment with SKF 525-A. This effect was explained by the prevention of release of heme from cytochrome P-450 by forming metabolic intermediate complexes with metabolites of SKF 525-A. On the other hand, poly (I.C) significantly suppressed P-450 content and benzphetamine N-demethylase and benzo [α] pyrene hydroxylase activities, even under simultaneous treatment with SKF 525-A. This inhibition by poly (I.C) was accompanied by weak staining of proteins corresponding to cytochrome P-450 in SDS gel electrophoresis. In addition, the activity of non-heme enzyme, 4-hydroxybiphenyl glucuronyltransferase, was suppressed by treatment with poly (I.C) but not by CoCl_2-treatment. These findings strongly suggested that, unlike CoCl_2,poly (I.C) suppressed cytochrome P-450 content and monooxygenase activities due to decreased synthesis or increased degradation of the apoprotein of cytochrome P-450 with slight contribution of the induced heme oxygenase.
- 公益社団法人日本薬学会の論文
著者
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Nagata Kiyoshi
九州大学 薬
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Nagata Kiyoshi
Faculty Of Pharmaceutical Sciences Kyushu University
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YOSHIMURA HIDETOSHI
Faculty of Pharmaceutical Sciences, Kyushu University
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MATSUNAGA Tamihide
Faculty of Pharmaceutical Sciences, Hokuriku University
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OGURI Kazuta
Faculty of Pharmaceutical Sciences, Kyushu University
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Tanaka Eiji
Faculty Of Pharmaceutical Sciences Kyushu University
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Yoshimura Hidetoshi
Faculty Of Pharmaceutical Sciences Kyushu University
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Yoshimura Hidetoshi
Faculty Of Pharmaceutical Sciences Kyushu University(present):department Of Food And Nutrition Nakam
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Oguri Kazuta
Faculty Of Pharmaceutical Sciences Kyushu University
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Oguri K
Faculty Of Pharmaceutical Sciences Kyushu University
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Oguri K
Kyushu Univ. Fukuoka Jpn
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Tanaka E
Univ. Tsukuba Ibaraki Jpn
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Mitsui Tetsuya
Faculty Of Pharmaceutical Sciences Kyushu University
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Yoshimura H
Faculty Of Pharmaceutical Sciences Kyushu University(present):department Of Food And Nutrition Nakam
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Matsunaga Tamihide
Faculty Of Pharmaceutical Sciences Kyushu University
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Yoshimura Hidetoshi
Department Of Food And Nutrition Nakamura Gakuen
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Nagata K
Faculty Of Pharmaceutical Sciences Kyushu University
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Tanaka Eiji
Faculty Of Marine Science Tokyo University Of Marine Science And Technology
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MATSUNAGA TAMIHIDE
Faculty of Pharmaceutical Sciences, Kyushu University
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