Inhibitory Effect of Cannabidiol Hydroxy-quinone, and Oxidative Product of Cannabidiol, on the Hepatic Microsomal Drug-Metabolizing Enzymes of Mice
スポンサーリンク
概要
- 論文の詳細を見る
Cannabidiol hydroxy-quinone (CBDHQ) was identified as an air oxidation product of cannabidiol (CBD). The in vitro incubation of mouse hepatic microsomes with CBDHQ resulted in a decrease of cytochrome P-450 content. CBDHQ inhibited the hepatic microsomal drug-metabolizing enzymes of mice. This inhibitory effect was stronger than that of CBD. CBDHQ (150μM) inhibited aniline hydroxylase, p-nitroanisole O-demethylase and aminopyrine N-demethylase in the microsomes by 70,52 and 77%, respectively, whereas the same concentration of CBD caused the inhibition by 39,30 and 26%, respectively. CBDHQ (91.5μM) significantly decreased total heme content by 21% and free SH groups by 11% in the microsomes. The results indicate that CBDHQ, which is an oxidation product of CBD, inhibits the hepatic microsomal drug-metabolizing enzymes through the decrease of cytochrome P-450 content.
- 社団法人日本薬学会の論文
著者
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YOSHIMURA HIDETOSHI
Faculty of Pharmaceutical Sciences, Kyushu University
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宇佐見 則行
九州保健福祉大学薬学部衛生薬学講座 九州保健福祉大学qol研究機構
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Usami Noriyuki
九州保健福祉大学 薬学部
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Usami Noriyuki
Department Of Hygienic Chemistry Faculty Of Pharmaceutical Sciences Hokuriku University
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Yamamoto Ikuo
Faculty of Education, Yokohama National University
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宇佐見 則行
北陸大・薬
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USAMI Noriyuki
Faculty of Health Science, Kyusyuu University of Health and Welfare
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WATANABE Kazuhito
Faculty of Pharmaceutical Sciences, Hokuriku University
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Yamamoto Ikuo
北陸大学 薬 衛化
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Usami N
Gifu Pharmaceutical Univ. Gifu Jpn
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Yoshimura Hidetoshi
Faculty Of Pharmaceutical Sciences Kyushu University
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Watanabe Kazuhito
Faculty Of Pharmaceutical Sciences Hokuriku University
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Watanabe Kazuhito
Faculty Of Pharmaceutical Sciences Kyushu University
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Yamamoto Ikuo
Faculty Of Education Yokohama National University
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